Evidence map›Paper›PMID 29714681›Full record

ArticleRadiology2018

Prevalence and Distribution of Atherosclerosis in a Low- to Intermediate-Risk Population: Assessment with Whole-Body MR Angiography.

Matthew A Lambert, Jonathan R Weir-McCall, Marco Salsano, Stephen J Gandy, Daniel Levin, Ian Cavin, Roberta Littleford, Jennifer A MacFarlane, Shona Z Matthew, Richard S Nicholas and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Potential Role of Somatostatin Receptor Scintigraphy forMolecular imaging and radionuclide therapy · 2023
    Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Matthew A LambertFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Jonathan R Weir-McCallFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Marco SalsanoFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).ORCID 0000-0001-6130-4989
Stephen J GandyFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Daniel LevinFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Ian CavinFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Roberta LittlefordFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Jennifer A MacFarlaneFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Shona Z MatthewFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Richard S NicholasFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Allan D StruthersFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Frank SullivanFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Shelley A HendersonFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Richard D WhiteFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
Jill J F BelchFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).
J Graeme HoustonFrom the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland (M.A.L., J.R.W.M., M.S., D.L., R.L., S.Z.M., A.D.S., J.J.F.B., J.G.H.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland (S.J.G., I.C., J.A.M., R.S.N., S.A.H.); Department of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada (F.S.); and Department of Clinical Radiology, University Hospital of Wales, Cardiff, Wales (R.D.W.).

Funding

Wellcome Trust
6 · The paper itself

Abstract

Purpose To quantify the burden and distribution of asymptomatic atherosclerosis in a population with a low to intermediate risk of cardiovascular disease. Materials and Methods Between June 2008 and February 2013, 1528 participants with 10-year risk of cardiovascular disease less than 20% were prospectively enrolled. They underwent whole-body magnetic resonance (MR) angiography at 3.0 T by using a two-injection, four-station acquisition technique. Thirty-one arterial segments were scored according to maximum stenosis. Scores were summed and normalized for the number of assessable arterial segments to provide a standardized atheroma score (SAS). Multiple linear regression was performed to assess effects of risk factors on atheroma burden. Results A total of 1513 participants (577 [37.9%] men; median age, 53.5 years; range, 40-83 years) completed the study protocol. Among 46 903 potentially analyzable segments, 46 601 (99.4%) were interpretable. Among these, 2468 segments (5%) demonstrated stenoses, of which 1649 (3.5%) showed stenosis less than 50% and 484 (1.0%) showed stenosis greater than or equal to 50%. Vascular stenoses were distributed throughout the body with no localized distribution. Seven hundred forty-seven (49.4%) participants had at least one stenotic vessel, and 408 (27.0%) participants had multiple stenotic vessels. At multivariable linear regression, SAS correlated with age (B = 3.4; 95% confidence interval: 2.61, 4.20), heart rate (B = 1.23; 95% confidence interval: 0.51, 1.95), systolic blood pressure (B = 0.02; 95% confidence interval: 0.01, 0.03), smoking status (B = 0.79; 95% confidence interval: 0.44, 1.15), and socioeconomic status (B = -0.06; 95% confidence interval: -0.10, -0.02) (P < .01 for all). Conclusion Whole-body MR angiography identifies early vascular disease at a population level. Although disease prevalence is low on a per-vessel level, vascular disease is common on a per-participant level, even in this low- to intermediate-risk cohort.

Indexed as

AdultAgedAged, 80 and overAtherosclerosisContrast MediaFemaleHumansImage EnhancementMagnetic Resonance AngiographyMaleMiddle AgedPrevalenceProspective StudiesRiskScotlandWhole Body ImagingContrast Media

Identifiers

PMID29714681
PMCPMC5979784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.