ArticleJournal of the American Chemical Society2018
An Enantioselective Cross-Dehydrogenative Coupling Catalysis Approach to Substituted Tetrahydropyrans.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ)-Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems.ChemistryOpen · 2026Review
- Si-H Activation via Dynamic Permutational Isomerism: A Ligand-Directed Route to Dehydrogenative Coupling.Angewandte Chemie (International ed. in English) · 2025Article
- Non-noble metal-catalyzed cross-dehydrogenation coupling (CDC) involving ether α-C(spBeilstein journal of organic chemistry · 2023Review
- Enantioselective Organocopper-Catalyzed Hetero Diels-Alder Reaction throughJournal of the American Chemical Society · 2022Article
- Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl-Cu Species.Journal of the American Chemical Society · 2022Article
- Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides.Journal of the American Chemical Society · 2021Article
- Radical coupling ofGreen synthesis and catalysis · 2020Article
- Enantioselective aerobic oxidative cross-dehydrogenative coupling of glycine derivatives with ketones and aldehydesChemical science · 2020Article
- Cross-dehydrogenative coupling enables enantioselective access to CFChemical science · 2020Article
- Synthetic Strategy for Pyrazolo[1,5-ACS omega · 2019Article
- Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(spACS omega · 2019Article
- Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
An enantioselective cross-dehydrogenative coupling (CDC) reaction to access tetrahydropyrans has been developed. This process combines in situ Lewis acid activation of a nucleophile in concert with the oxidative formation of a transient oxocarbenium electrophile, leading to a productive and highly enantioselective CDC. These advances represent one of the first successful applications of CDC for the enantioselective couplings of unfunctionalized ethers. This system provides efficient access to valuable tetrahydropyran motifs found in many natural products and bioactive small molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.