Evidence map›Paper›PMID 29714357›Full record

ArticleBrainlesion : glioma, multiple sclerosis, stroke and traumatic brain injuries. BrainLes (Workshop)2018

Joint Intensity Fusion Image Synthesis Applied to Multiple Sclerosis Lesion Segmentation.

Greg M Fleishman, Alessandra Valcarcel, Dzung L Pham, Snehashis Roy, Peter A Calabresi, Paul Yushkevich, Russell T Shinohara, Ipek Oguz

Abstract read
In one paragraph

Article in Brainlesion : glioma, multiple sclerosis, stroke and traumatic brain injuries. BrainLes (Workshop), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Self-fusion for OCT noise reduction.Proceedings of SPIE--the International Society for Optical Engineering · 2020
    Article
  5. LIFE: A Generalizable Autodidactic Pipeline for 3D OCT-A Vessel Segmentation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Greg M FleishmanDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alessandra ValcarcelDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dzung L PhamCNRM, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Snehashis RoyCNRM, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Peter A CalabresiDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Paul YushkevichDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Russell T ShinoharaDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ipek OguzDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
Adaptive Large-Scale Framework for Automatic Biomedical Image SegmentationR01EB017255 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI YUSHKEVICH, PAUL A. · 2014 to 2018
$3.0M
Statistical methods for large and complex databases of ultra-high-dimensionalR01NS085211 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2013 to 2017
$1.8M
Brain Image Analysis Tools for Quantitative Longitudinal Assessment of MSR01NS070906 · NINDS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PHAM, DZUNG L · 2010 to 2014
$1.7M
Early detection of Huntington's Disease: Longitudinal analysis of basal ganglia and cortical thicknessR01NS094456 · NINDS · VANDERBILT UNIVERSITY · PI OGUZ, IPEK · 2016 to 2019
$1.3M
Spatiotemporal Modeling of MRI Brain Lesion Trajectories of Biomarker DiscoveryR21NS093349 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ELOYAN, ANI, SHINOHARA, RUSSELL TAKESHI · 2016 to 2017
$454k
NIBIB NIH HHS R01 EB017255NINDS NIH HHS R01 NS070906NINDS NIH HHS R01 NS082347NINDS NIH HHS R01 NS085211NINDS NIH HHS R01 NS094456NINDS NIH HHS R21 NS093349
6 · The paper itself

Abstract

We propose a new approach to Multiple Sclerosis lesion segmentation that utilizes synthesized images. A new method of image synthesis is considered: joint intensity fusion (JIF). JIF synthesizes an image from a library of deformably registered and intensity normalized atlases. Each location in the synthesized image is a weighted average of the registered atlases; atlas weights vary spatially. The weights are determined using the joint label fusion (JLF) framework. The primary methodological contribution is the application of JLF to MRI signal directly rather than labels. Synthesized images are then used as additional features in a lesion segmentation task using the OASIS classifier, a logistic regression model on intensities from multiple modalities. The addition of JIF synthesized images improved the Dice-Sorensen coefficient (relative to manually drawn gold standards) of lesion segmentations over the standard model segmentations by 0.0462 ± 0.0050 (mean ± standard deviation) at optimal threshold over all subjects and 10 separate training/testing folds.

Identifiers

PMID29714357
PMCPMC5920684

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.