Evidence map›Paper›PMID 29714177›Full record

ArticleJournal of synchrotron radiation2018

A convolutional neural network-based screening tool for X-ray serial crystallography.

Tsung Wei Ke, Aaron S Brewster, Stella X Yu, Daniela Ushizima, Chao Yang, Nicholas K Sauter

Open access · hybridAbstract read
In one paragraph

Article in Journal of synchrotron radiation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 63 citations in OpenAlex.

  1. A short history of Auto-Rickshaw.Acta crystallographica. Section D, Structural biology · 2026
    Review
  2. Review
  3. Article
  4. Machine learning for the classification of serial electron diffraction patterns: synthetic data.Acta crystallographica. Section A, Foundations and advances · 2025
    Article
  5. Deep-learning map segmentation for protein X-ray crystallographic structure determination.Acta crystallographica. Section D, Structural biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. TheJournal of applied crystallography · 2024
    Article
  10. Deep learning applications in protein crystallography.Acta crystallographica. Section A, Foundations and advances · 2024
    Review
  11. Deep residual networks for crystallography trained on synthetic data.Acta crystallographica. Section D, Structural biology · 2024
    Article
  12. Article
  13. Review
  14. Explainable machine learning for diffraction patterns.Journal of applied crystallography · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Best practices for time-resolved serial synchrotron crystallography.Acta crystallographica. Section D, Structural biology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tsung Wei KeInternational Computer Science Institute, University of California Berkeley, Berkeley, CA 94704, USA.
Aaron S BrewsterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Stella X YuInternational Computer Science Institute, University of California Berkeley, Berkeley, CA 94704, USA.
Daniela UshizimaComputational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Chao YangComputational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Nicholas K SauterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Lawrence Berkeley National Laboratory · USInternational Computer Science Institute · USUniversity of California, Berkeley · US

Funding

U.S. Department of Energy DE-AC02-05CH11231U.S. Department of Energy DE-AC02-76SF00515
6 · The paper itself

Abstract

A new tool is introduced for screening macromolecular X-ray crystallography diffraction images produced at an X-ray free-electron laser light source. Based on a data-driven deep learning approach, the proposed tool executes a convolutional neural network to detect Bragg spots. Automatic image processing algorithms described can enable the classification of large data sets, acquired under realistic conditions consisting of noisy data with experimental artifacts. Outcomes are compared for different data regimes, including samples from multiple instruments and differing amounts of training data for neural network optimization.

Indexed as

convolutional neural networksdeep learningmacromolecular structureserial crystallographyX-ray free-electron laser

Identifiers

PMID29714177
PMCPMC5929353
OpenAlexW2802285417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.