ArticlePersonalized medicine2018
Clinical application of pharmacogenetics in pain management.
Article in Personalized medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial.Pharmacogenomics · 2019Trial
- CYP2D6-Guided Opioid Therapy for Chronic Pain: A Multi-Center Pragmatic Randomized Controlled Trial.Clinical pharmacology and therapeutics · 2026Article
- Integrating genetic insights into pain management and opioid use optimization in chronic pain and substance abuse populations.Exploratory research in clinical and social pharmacy · 2025Article
- Utilizing Pharmacogenetic Results to Optimize Medication Management in Hospice Care: A Pilot Study.Journal of personalized medicine · 2025Article
- Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the IGNITE ADOPT PGx investigators.Clinical and translational science · 2024Article
- Evaluation of Pupillometry for CYP2D6 Phenotyping in Children Treated with Tramadol.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Evidence Regarding Pharmacogenetics in Pain Management and Cancer.The oncologist · 2023Article
- STOP Pain Project-Opioid Response in Pediatric Cancer Patients and Gene Polymorphisms of Cytokine Pathways.Pharmaceutics · 2022Article
- The Role of Pharmacogenomics in Postoperative Pain Management.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.The oncologist · 2021Article
- Different Pharmacokinetics of Tramadol,Frontiers in pharmacology · 2021Article
- Personalized pediatric anesthesia and pain management: problem-based review.Pharmacogenomics · 2020Review
- Genetic Polymorphisms of Cytokines Might Affect Postoperative Sufentanil Dosage for Analgesia in Patients.Journal of pain research · 2020Article
- Potential role of pharmacogenomics testing in the setting of enhanced recovery pathways after surgery.Pharmacogenomics and personalized medicine · 2019Article
- Genetics of perioperative pain management.Current opinion in anaesthesiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
There is growing experience translating genomic data into clinical practice, as seen with the Implementing GeNomics In pracTicE (IGNITE) network. A primary example is the influence of CYP2D6 genotype on the beneficial and adverse effects of some opioids. Clinical recommendations exist to guide drug therapy based on CYP2D6 genotype for codeine, tramadol, oxycodone and hydrocodone, although the level of supporting evidence differs by drug. Limited evidence also supports the use of genetic data to guide other medications in chronic pain therapy, including tricyclic antidepressants and celecoxib. Pragmatic clinical trial data are needed in this area to better understand the impact of diverse populations, therapeutic interventions and clinical care environments on genotype-guided drug therapy for chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.