Evidence map›Paper›PMID 29713826›Full record

ArticleVirchows Archiv : an international journal of pathology2018

Pathologic significance of AKT, mTOR, and GSK3β proteins in oral squamous cell carcinoma-affected patients.

Flávia Sayuri Matsuo, Marília Ferreira Andrade, Adriano Mota Loyola, Sindeval José da Silva, Marcelo José Barbosa Silva, Sérgio Vitorino Cardoso, Paulo Rogério de Faria

Abstract read
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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  13. Autophagy-A Hidden but Important Actor on Oral Cancer Scene.International journal of molecular sciences · 2020
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  15. Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer.Biochimica et biophysica acta. Molecular cell research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Flávia Sayuri MatsuoDepartment of Cell and Molecular Biology and Pathogenic Bioagents, School of Medicine, University of São Paulo, 1900 Bandeirantes Avenue, Ribeirão Preto, São Paulo, Brazil.
Marília Ferreira AndradeDepartment of Immunology, Institute of Biomedical Science, Federal University of Uberlândia, 1720 Pará Avenue, Block 4C, Uberlândia, Minas Gerais, 38400-902, Brazil.
Adriano Mota LoyolaDepartment of Oral Pathology, School of Dentistry, Federal University of Uberlândia, 1720 Pará Avenue, Block 4L, Uberlândia, Minas Gerais, 38400-902, Brazil.
Sindeval José da SilvaDepartment of Surgery, School of Medicine, Federal University of Uberlândia, 1720 Pará Avenue, Uberlândia, Minas Gerais, 38400-902, Brazil.
Marcelo José Barbosa SilvaDepartment of Immunology, Institute of Biomedical Science, Federal University of Uberlândia, 1720 Pará Avenue, Block 4C, Uberlândia, Minas Gerais, 38400-902, Brazil.
Sérgio Vitorino CardosoDepartment of Oral Pathology, School of Dentistry, Federal University of Uberlândia, 1720 Pará Avenue, Block 4L, Uberlândia, Minas Gerais, 38400-902, Brazil.
Paulo Rogério de FariaDepartment of Morphology, Institute of Biomedical Science, Federal University of Uberlândia, 1720 Pará Avenue, Block 2B, Uberlândia, Minas Gerais, 38400-902, Brazil. paulo.faria@ufu.br.
Universidade Federal de Uberlândia · BRUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 471130/2013-13Fundação de Amparo à Pesquisa do Estado de Minas Gerais (BR) APQ-01746-13
6 · The paper itself

Abstract

Phosphatidylinositol-3-kinases are kinases that lead to AKT phosphorylation and thus mTOR and GSK3β activation. These proteins are linked to tumorigenesis, but their roles in driving cervical lymph node (CLN) metastasis of oral squamous cell carcinoma (OSCC) cells are unknown. This study aimed to investigate the role of AKT, mTOR, and GSK3β proteins in the occurrence of CLN metastasis in OSCC patients. Ninety and 18 paraffin-embedded OSCC and oral mucosa samples were included, respectively. We divided our OSCC patients into non-metastasizing (PNM) and metastasizing (PM) groups, and the expression of total AKT, pAKT1

Indexed as

AdultAgedCarcinoma, Squamous CellFemaleGlycogen Synthase Kinase 3 betaHumansLymphatic MetastasisMaleMiddle AgedMouth NeoplasmsProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesGlycogen Synthase Kinase 3 betaMTOR protein, humanProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAKTCervical lymph node metastasisGlycogen synthase kinase-3β, prognosismTOROral squamous cell carcinoma

Identifiers

PMID29713826
OpenAlexW2799551287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.