Evidence map›Paper›PMID 29713797›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

Whole egg consumption and cortical bone in healthy children.

L M Coheley, J M Kindler, E M Laing, A Oshri, K M Hill Gallant, S J Warden, M Peacock, C M Weaver, R D Lewis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. The Impact of Whole Egg Consumption on Bone Accrual in Healthy Children: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

L M CoheleyDepartment of Foods and Nutrition, The University of Georgia, 279 Dawson Hall, 305 Sanford Drive, Athens, GA, USA.
J M KindlerDepartment of Nutrition Science, Purdue University, Stone Hall 220-B, 770 West State Street, West Lafayette, IN, USA.
E M LaingDepartment of Foods and Nutrition, The University of Georgia, 279 Dawson Hall, 305 Sanford Drive, Athens, GA, USA.
A OshriDepartment of Human Development and Family Science, The University of Georgia, 208 Family Science Center (House A), 403 Sanford Drive, Athens, GA, USA.
K M Hill GallantDepartment of Nutrition Science, Purdue University, STON 207, 700 West State Street, West Lafayette, IN, USA.
S J WardenSchool of Health and Rehabilitation Sciences, Indiana University-Purdue University Indianapolis, 1140 West Michigan Street, Indianapolis, IN, USA.
M PeacockDepartment of Medicine, Indiana University, Gatch Hall Suite 265, 1120 West Michigan Street, Indianapolis, IN, USA.
C M WeaverDepartment of Nutrition Science, Purdue University, Stone Hall 220-B, 770 West State Street, West Lafayette, IN, USA.
R D LewisDepartment of Foods and Nutrition, The University of Georgia, 279 Dawson Hall, 305 Sanford Drive, Athens, GA, USA. rdlewis@uga.edu.
University of Georgia · USState Street (United States) · USIndiana University – Purdue University Indianapolis · USUniversity of Indianapolis · US

Funding

Supplemental Vitamin D and Functional Outcomes in Early AdolescenceR01HD057126 · NICHD · UNIVERSITY OF GEORGIA · PI LEWIS, RICHARD D · 2009 to 2010
$2.2M
Phosphorus Absorption and Balance in Normal Physiology and Chronic Kidney DiseaseK01DK102864 · NIDDK · UNIVERSITY OF MINNESOTA · PI GALLANT, KATHLEEN M HILL · 2015 to 2019
$692k
Egg Nutrition Center 25 - 21 - RC296 - 214National Institute of Food and Agriculture GEO00797National Institute of Food and Agriculture GEO00798National Institutes of Health RO1HD057126NICHD NIH HHS R01 HD057126NIDDK NIH HHS K01 DK102864
6 · The paper itself

Abstract

Eggs contain bioactive compounds thought to benefit pediatric bone. This cross-sectional study shows a positive link between childhood egg intake and radius cortical bone. If randomized trials confirm our findings, incorporating eggs into children's diets could have a significant impact in preventing childhood fractures and reducing the risk of osteoporosis.

introductionThis study examined the relationships between egg consumption and cortical bone in children.

methodsThe cross-sectional study design included 294 9-13-year-old black and white males and females. Three-day diet records determined daily egg consumption. Peripheral quantitative computed tomography measured radius and tibia cortical bone. Body composition and biomarkers of bone turnover were assessed using dual-energy X-ray absorptiometry and ELISA, respectively.

resultsEgg intake was positively correlated with radius and tibia cortical bone mineral content (Ct.BMC), total bone area, cortical area, cortical thickness, periosteal circumference, and polar strength strain index in unadjusted models (r = 0.144-0.224, all P < 0.050). After adjusting for differences in race, sex, maturation, fat-free soft tissue mass (FFST), and protein intakes, tibia relationships were nullified; however, egg intake remained positively correlated with radius Ct.BMC (r = 0.138, P = 0.031). Egg intake positively correlated with total body bone mineral density, BMC, and bone area in the unadjusted models only (r = 0.119-0.224; all P < 0.050). After adjusting for covariates, egg intake was a positive predictor of radius FFST (β = 0.113, P < 0.050) and FFST was a positive predictor of Ct.BMC (β = 0.556, P < 0.050) in path analyses. There was a direct influence of egg on radius Ct.BMC (β = 0.099, P = 0.035), even after adjusting for the mediator, FFST (β = 0.137, P = 0.020). Egg intake was positively correlated with osteocalcin in both the unadjusted (P = 0.005) and adjusted (P = 0.049) models.

conclusionIf the positive influence of eggs on Ct.BMC observed in this study is confirmed through future randomized controlled trials, whole eggs may represent a viable strategy to promote pediatric bone development and prevent fractures.

Indexed as

Absorptiometry, PhotonAdolescentAnthropometryBiomarkersBone DensityBone DevelopmentBone RemodelingChildChild Nutritional Physiological PhenomenaCortical BoneCross-Sectional StudiesDietEggsFeeding BehaviorFemaleHumansBiomarkersCortical boneEggFat-free soft tissuepQCT

Identifiers

PMID29713797
PMCPMC6604058
OpenAlexW2799491307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.