Evidence map›Paper›PMID 29713796›Full record

ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

Is calcifediol better than cholecalciferol for vitamin D supplementation?

J M Quesada-Gomez, R Bouillon

Registry-linked trialAbstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07479303 (Evaluation of Vitamin D Status in Young Medical Residents at the Reina Sofia University Hospital in Cordoba), which is not on this map. Cited by 109 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 5 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07479303 completednot on this mapstarted 2025, after this paper: background citation

Evaluation of Vitamin D Status in Young Medical Residents at the Reina Sofia University Hospital in Cordoba

Typeobservational_patient_registrySponsorMaimónides Biomedical Research Institute of CórdobaRan2025 to 2025Enrolled30ConditionsVitamin D DeficiencyArmsCalcifediol (Vitamin D)
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 5 syntheses or guidelines pooled it, 214 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Effect of calcifediol and cholecalciferol on muscle function in postmenopausal women: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Treatment With 25-Hydroxyvitamin DEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2021
    Trial
  11. Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Review
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

J M Quesada-GomezInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC) & Unidad de Gestión Clínica (UGC) de Endocrinología y Nutrición, Hospital Universitario Reina Sofía, Universidad de Córdoba, Avda. Menéndez Pidal s/n, 14004, Córdoba, Spain.
R BouillonDepartment of Chronic Diseases, Metabolism and Ageing, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Herestraat, ON 1/902, 3000, Leuven, Belgium. roger.bouillon@kuleuven.be.ORCID http://orcid.org/0000-0002-6446-3763
Instituto Maimónides de Investigación Biomédica de Córdoba · ESKU Leuven · BE

Funding

Spain and EU PI15/01857
6 · The paper itself

Abstract

Modest and even severe vitamin D deficiency is widely prevalent around the world. There is consensus that a good vitamin D status is necessary for bone and general health. Similarly, a better vitamin D status is essential for optimal efficacy of antiresorptive treatments. Supplementation of food with vitamin D or using vitamin D supplements is the most widely used strategy to improve the vitamin status. Cholecalciferol (vitamin D

Indexed as

Dietary SupplementsAdministration, OralCalcifediolCholecalciferolComparative Effectiveness ResearchDose-Response Relationship, DrugHumansVitamin DVitamin D Deficiency25-hydroxyvitamin DCalcifediolCholecalciferolVitamin DAbsorption of vitamin D (metabolites)Calcifediol or 25-hydroxyvitamin D3 or 25OHD oral supplementationCholecalciferol or vitamin D3 oral supplementationConversion efficacy of vitamin D into 25OHDErgocalciferol or vitamin D2 oral supplementationMetabolism of vitamin DVitamin D deficiencyVitamin D supplementation

Identifiers

PMID29713796
OpenAlexW2802788160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.