ArticlePsychopharmacology2018
Cognitive profile of ketamine-dependent patients compared with methamphetamine-dependent patients and healthy controls.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 35 citations in OpenAlex.
- The landscape of ketamine use disorder: Patient experiences and perspectives on current treatment options.Addiction (Abingdon, England) · 2025Article
- Disturbed relationship between glucocorticoid receptor and 5-HT1AR/5-HT2AR in ADHD rats: A correlation study.Frontiers in neuroscience · 2022Article
- Krill Oil Alleviated Methamphetamine-Induced Memory ImpairmentFrontiers in pharmacology · 2021Article
- Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder: A Review.JAMA psychiatry · 2020Review
- Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers.Therapeutic advances in psychopharmacology · 2020Article
- Chronic ketamine abuse is associated with orexin-A reduction and ACTH elevation.Psychopharmacology · 2020Article
- Methamphetamine Users Show No Behavioral Deficits in Response Selection After Protracted Abstinence.Frontiers in psychiatry · 2019Article
- Difference in long-term relapse rates between youths with ketamine use and those with stimulants use.Substance abuse treatment, prevention, and policy · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundKetamine has emerged as a major substance of abuse worldwide and has been listed with methamphetamine (METH) as two of the most widely available illicit substances in Taiwan. Only a few studies have examined the long-term consequences of chronic and heavy ketamine abuse. We compared the cognitive function of ketamine-dependent patients with that of METH-dependent patients and healthy controls.
methodsWe recruited 165 participants (58 ketamine-dependent and 49 METH-dependent patients who sought treatment and 58 healthy controls) and evaluated them by using a cognitive test battery, the Brief Assessment of Cognition in Schizophrenia, with scores being estimated in reference to normative data in general population.
resultsThe ketamine-dependent patients had significantly poorer performance than did the controls in many cognitive tests, including verbal memory, motor speed, verbal fluency, and attention and processing speed, and the battery as a whole. METH-dependent patients exhibited poorer function in motor speed, verbal fluency, and attention and processing speed. The ketamine group performed poorer than did METH group in the domains of verbal memory, working memory, and attention and processing speed and the composite battery scores. A previous experience of ketamine-induced psychotomimetic symptoms, using higher doses of ketamine, and longer abstinence appeared to be associated with performance in some tests; however, the significance disappeared after multiple comparison correction.
conclusionsThe ketamine-dependent patients had impaired cognitive function, and METH-dependent patients exhibited intermediate performance between ketamine-dependent patients and healthy controls. Given the growing population of ketamine abusers, public education on the cognitive consequences should be provided.
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