Evidence map›Paper›PMID 29713775›Full record

ArticleEuropean radiology2018

Tibial tuberosity to trochlear groove distance and its association with patellofemoral osteoarthritis-related structural damage worsening: data from the osteoarthritis initiative.

Arya Haj-Mirzaian, Ali Guermazi, Michael Hakky, Christopher Sereni, Bashir Zikria, Frank W Roemer, Miho J Tanaka, Andrew J Cosgarea, Shadpour Demehri

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Age-Dependent Susceptibility to Mechanical Unloading-Induced Femoral Morphological Changes and Patellar Instability in a Rat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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  7. Review
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  12. Influence of medial open wedge high tibial osteotomy on tibial tuberosity-trochlear groove distance.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023
    Article
  13. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arya Haj-MirzaianThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 4240, Baltimore, MD, 21287, USA. arya.mirzaian@gmail.com.
Ali GuermaziDepartment of Radiology, Boston University School of Medicine, Boston, MA, USA.
Michael HakkyDepartment of Radiology, Florida Hospital, Maitland, FL, USA.
Christopher SereniDepartment of Radiology, University of Massachusetts Medical School, Boston, MA, USA.
Bashir ZikriaDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Frank W RoemerDepartment of Radiology, Boston University School of Medicine, Boston, MA, USA.
Miho J TanakaDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Andrew J CosgareaDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Shadpour DemehriThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 4240, Baltimore, MD, 21287, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine whether the tibial tuberosity-to-trochlear groove (TT-TG) distance is associated with concurrent patellofemoral joint osteoarthritis (OA)-related structural damage and its worsening on 24-month follow-up magnetic resonance imaging (MRI) in participants in the Osteoarthritis Initiative (OAI).

methodsSix hundred subjects (one index knee per participant) were assessed. To evaluate patellofemoral OA-related structural damage, baseline and 24-month semiquantitative MRI Osteoarthritis Knee Score (MOAKS) variables for cartilage defects, bone marrow lesions (BMLs), osteophytes, effusion, and synovitis were extracted from available readings. The TT-TG distance was measured in all subjects using baseline MRIs by two musculoskeletal radiologists. The associations between baseline TT-TG distance and concurrent baseline MOAKS variables and their worsening in follow-up MRI were investigated using regression analysis adjusted for variables associated with tibiofemoral and patellofemoral OA.

resultsAt baseline, increased TT-TG distance was associated with concurrent lateral patellar and trochlear cartilage damages, BML, osteophytes, and knee joint effusion [cross-sectional evaluations; overall odds ratio 95% confidence interval (OR 95% CI): 1.098 (1.045-1.154), p < 0.001]. In the longitudinal analysis, increased TT-TG distance was significantly related to lateral patellar and trochlear cartilage, BML, and joint effusion worsening (overall OR 95% CI: 1.111 (1.056-1.170), p < 0.001).

conclusionsTT-TG distance was associated with simultaneous lateral patellofemoral OA-related structural damage and its worsening over 24 months. Abnormally lateralized tibial tuberosity may be considered as a risk factor for future patellofemoral OA worsening. KEY POINTS: • Excessive TT-TG distance on MRI is an indicator/predictor of lateral-patellofemoral-OA. • TT-TG is associated with simultaneous lateral-patellofemoral-OA (6-17% chance-increase for each millimeter increase). • TT-TG is associated with longitudinal (24-months) lateral-patellofemoral-OA (5-15% chance-increase for each millimeter).

Indexed as

Cross-Sectional StudiesDisease ProgressionFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneeOsteophytePatellofemoral JointPrognosisSeverity of Illness IndexTibiaTime FactorsKneeMagnetic resonance imagingOsteoarthritisPatella

Identifiers

PMID29713775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.