Evidence map›Paper›PMID 29713770›Full record

ArticleEuropean radiology2018

Comprehensive morphologic and functional imaging of heart transplant patients: first experience with dynamic perfusion CT.

S Oebel, S Hamada, K Higashigaito, J von Spiczak, E Klotz, F Enseleit, R Hinzpeter, F Ruschitzka, R Manka, H Alkadhi

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Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

S OebelInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
S HamadaInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
K HigashigaitoInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
J von SpiczakInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
E KlotzSiemens Healthineers, Computed Tomography, DE-91301, Forchheim, Germany.
F EnseleitDepartment of Cardiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
R HinzpeterInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
F RuschitzkaDepartment of Cardiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
R MankaInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland.
H AlkadhiInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland. hatem.alkadhi@usz.ch.ORCID http://orcid.org/0000-0002-2581-2166

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to assess the diagnostic performance of a combined protocol with coronary computed tomography angiography (CCTA) and stress CT perfusion imaging (CTP) in heart transplant patients for comprehensive morphological and functional imaging.

methodsIn this prospective study, 13 patients undergoing routine follow-up 8±6 years after heart transplantation underwent CCTA and dynamic adenosine stress CTP using a third-generation dual-source CT scanner, cardiac magnetic resonance (MR) adenosine stress perfusion imaging at 1.5 T, and catheter coronary angiography. In CCTA stenoses >50% luminal diameter narrowing were noted. Myocardial perfusion deficits were documented in CTP and MR. Quantitative myocardial blood flow (MBF) was calculated with CTP. Left ventricular ejection fraction was determined on cardiac MR cine images. Radiation doses of CT were determined.

resultsOne of the 13 patients had to be excluded because of severe motion artifacts. CCTA identified three patients with stenosis >50%, which were confirmed with catheter coronary angiography. CTP showed four patients with stress-induced myocardial hypoperfusion, which were confirmed by MR stress perfusion imaging. Quantitative analysis of global MBF showed lower mean values as compared to known reference values (MBF under stress 125.5 ± 34.5 ml/100 ml/min). Average left ventricular ejection fraction was preserved (56 ± 5%).

conclusionsIn heart transplant patients, a comprehensive CT protocol for the assessment of morphology and function including CCTA and CTP showed good concordance to results from MR perfusion imaging and catheter coronary angiography. KEY POINTS: • Stress CT perfusion imaging enables the detection of myocardial ischemia • CT myocardial perfusion imaging can be combined with coronary computed tomography angiography • Combining perfusion and coronary CT imaging is accurate in heart transplant patients • CT myocardial perfusion imaging can be performed at a reasonable radiation dose.

Indexed as

Heart TransplantationAdultAgedComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisFemaleHeartHumansMaleMiddle AgedMyocardial IschemiaMyocardial Perfusion ImagingProspective StudiesSensitivity and SpecificityCoronary angiographyMagnetic resonance imagingMultidetector-row computed tomographyMyocardial perfusion imagingTransplantation

Identifiers

PMID29713770

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