ArticleEuropean radiology2018
Evaluation of T categories for pure ground-glass nodules with semi-automatic volumetry: is mass a better predictor of invasive part size than other volumetric parameters?
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Epidemiology of Ground Glass Opacity Lung Adenocarcinoma: A Network-Based Cumulative Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Tumor Mass Is a Better Prognostic Factor Than Consolidation-to-Tumor Ratio in Invasive Lung Adenocarcinoma Manifest Difficult-to-Measure Solid Portion.JTO clinical and research reports · 2026Article
- Correlation between CT growth patterns and invasiveness progression in neoplastic subcentimeter sub-solid nodules.Annals of medicine · 2025Article
- Article
- An artificial intelligence algorithm for the detection of pulmonary ground-glass nodules on spectral detector CT: performance on virtual monochromatic images.BMC medical imaging · 2024Article
- Predicting the Invasiveness of Pulmonary Adenocarcinomas in Pure Ground-Glass Nodules Using the Nodule Diameter: A Systematic Review, Meta-Analysis, and Validation in an Independent Cohort.Diagnostics (Basel, Switzerland) · 2024Review
- Prognostic impact of deep learning-based quantification in clinical stage 0-I lung adenocarcinoma.European radiology · 2023Article
- Radiomics-based analysis of CT imaging for the preoperative prediction of invasiveness in pure ground-glass nodule lung adenocarcinomas.Insights into imaging · 2023Article
- Radiomics for lung adenocarcinoma manifesting as pure ground-glass nodules: invasive prediction.European radiology · 2020Article
- Determining the invasiveness of pure ground-glass nodules using dual-energy spectral computed tomography.Translational lung cancer research · 2020Article
- Article
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Abstract
objectivesThis study aimed to investigate the diagnostic advantage of nodule mass in differentiating invasive pulmonary adenocarcinomas (IPAs) among pure ground-glass nodules (pGGNs) over other volumetric measurements. Another aim of this study was to analyse the correlation between volumetric measurements on computed tomography (CT) scans and the pathological invasive component size.
methodsThis Institutional Review Board-approved retrospective study included 117 patients (men:women = 53:64; mean age, 57.3 years) with 117 pGGNs. Semi-automatic segmentation was performed for all nodules, and volumetric measurements, such as nodule volume, attenuation, mass, two-dimensional (2D) average diameter and three-dimensional (3D) longest diameter, were obtained. Receiver operating characteristic (ROC) curve analyses were performed to evaluate the diagnostic performances of the volumetric parameters in discriminating IPAs. Spearman correlation coefficients were calculated between the volumetric measurements and the invasive component size.
resultsArea under the ROC curve for mass was 0.792 (95% CI, 0.691-0.872) in non-enhanced CT and 0.730 (95% CI, 0.607-0.832) in contrast-enhanced CT. Nodule mass was not superior to 2D average diameter for the differentiation of IPAs in both non-enhanced (0.792 vs 0.780; p = 0.501) CT and contrast-enhanced CT scans (0.730 vs 0.700; p = 0.319). The correlation between the volumetric measurements (mass, 3D longest diameter and 2D average diameter) and the invasive component size was moderate (Spearman's rho, 0.401-0.422) in non-enhanced CT and weak (Spearman's rho, 0.276-0.310) in contrast-enhanced CT.
conclusionsNodule mass measurement had no strength over other volumetric parameters for the prediction of pathological invasiveness in the diagnosis of pGGNs. KEY POINTS: • Mass is not superior to other volumetric measurements for the diagnosis of pure ground-glass nodules. • Mass and two-dimensional average diameter exhibited comparable performance for the discrimination of invasive adenocarcinomas among pure ground-glass nodules. • The diagnostic performance of volumetric measurements was lower on contrast-enhanced CT scans. • The correlation between the volumetric measurements and the invasive component size was moderate on non-enhanced CT scans and weak on contrast-enhanced CT scans.
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