Evidence map›Paper›PMID 29713744›Full record

ReviewSeminars in immunopathology2018

Skin neurogenic inflammation.

Jae Eun Choi, Anna Di Nardo

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 2 pooled it
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 2 syntheses or guidelines pooled it, 302 citations in OpenAlex.

  1. Pooled it
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  17. Cross-Organ Neuroimmunology of Behavior.Annual review of immunology · 2026
    Review
  18. Keratinocytes: pleiotropic orchestrators of cutaneous immunity and Inflammation - Emerging therapeutic paradigms in dermatological pathologies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  19. The exposomal imprint on rosacea: More than skin deep.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  20. Review

124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jae Eun ChoiDepartment of Dermatology, University of California San Diego, 9500 Gilman Drive #0869, La Jolla, CA, 92093, USA.
Anna Di NardoDepartment of Dermatology, University of California San Diego, 9500 Gilman Drive #0869, La Jolla, CA, 92093, USA. adinardo@ucsd.edu.ORCID http://orcid.org/0000-0002-5575-9968
University of California San Diego · US

Funding

Mast cells in skin innate immune defenseR01AI093957 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DI NARDO, ANNA · 2011 to 2023
$4.6M
The Microbiome Drives Masts Cell Recruitment in the SkinR01AI106874 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DI NARDO, ANNA · 2015 to 2019
$2.0M
Bacterial Mast cell conditioning modulates skin allergic reactionsR21AI123729 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DI NARDO, ANNA · 2016 to 2017
$426k
Mast cell controls pathogen entrance by the expression of antimicrobial peptidesR21AI074766 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DI NARDO, ANNA · 2008 to 2009
$425k
National Institute of Allergy and Infectious Diseases 1 R21 AI123729-01NIAID NIH HHS R01 AI093957NIAID NIH HHS R01 AI106874NIAID NIH HHS R21 AI074766
6 · The paper itself

Abstract

The epidermis closely interacts with nerve endings, and both epidermis and nerves produce substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin gene-related protein (CGRP), are produced by sensory nerves in the dermis; they induce mast cells to release vasoactive amines that facilitate infiltration of neutrophils and T cells. Some receptors are more important than others in the generation of itch. The Mas-related G protein-coupled receptors (Mrgpr) family as well as transient receptor potential ankyrin 1 (TRPA1) and protease activated receptor 2(Par2) have important roles in itch and inflammation. The activation of MrgprX1 degranulates mast cells to communicate with sensory nerve and cutaneous cells for developing neurogenic inflammation. Mrgprs and transient receptor potential vanilloid 4 (TRPV4) are crucial for the generation of skin diseases like rosacea, while SP, CGRP, somatostatin, β-endorphin, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP) can modulate the immune system during psoriasis development. The increased level of SP, in atopic dermatitis, induces the release of interferon (IFN)-γ, interleukin (IL)-4, tumor necrosis factor (TNF)-α, and IL-10 from the peripheral blood mononuclear leukocytes. We are finally starting to understand the intricate connections between the skin neurons and resident skin cells and how their interaction can be key to controlling inflammation and from there the pathogenesis of diseases like atopic dermatitis, psoriasis, and rosacea.

Indexed as

AnimalsHumansNeurogenic InflammationNeuropeptidesSkinSkin DiseasesNeuropeptides

Identifiers

PMID29713744
PMCPMC6047518
OpenAlexW2802723594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.