Evidence map›Paper›PMID 29713658›Full record

ArticleCurrent opinion in behavioral sciences2018

Regulation of habit formation in the dorsal striatum.

Melissa Malvaez, Kate M Wassum

Abstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Habit Formation to Enhance Implementation of Evidence-based Practice.Administration and policy in mental health · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Neural Compensation in the Medial Prefrontal Cortex Preserves Self-Prioritization in Aging: A Computational Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  13. Goal-directed actions and habits in head-fixed mice.Frontiers in behavioral neuroscience · 2026
    Article
  14. Article
  15. Article
  16. Article
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  19. Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melissa MalvaezDept. of Psychology, UCLA, Los Angeles, CA 90095, USA.
Kate M WassumDept. of Psychology, UCLA, Los Angeles, CA 90095, USA.

Funding

Basolateral Amygdala Rapid Glutamate Signaling During Reward Decision-MakingR01DA035443 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kate M Wassum · 2013 to 2026
$5.7M
Cholinergic regulation of striatal neurochemistry in cue-triggered decision-makingR01MH106972 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI OSTLUND, SEAN BJORN · 2016 to 2020
$2.5M
NIDA NIH HHS R01 DA035443NIMH NIH HHS R01 MH106972
6 · The paper itself

Abstract

Habits are an essential and pervasive component of our daily lives that allow us to efficiently perform routine tasks. But their disruption contributes to the symptoms that underlie many psychiatric diseases. Emerging data are revealing the cellular and molecular mechanisms of habit formation in the dorsal striatum. New data suggest that in both the dorsolateral and dorsomedial striatum histone deacetylase (HDAC) activity acts as a critical negative regulator of the transcriptional processes underlying habit formation. In this review, we discuss this recent work and draw conclusions relevant to the treatment of diseases marked by maladaptive habits.

Identifiers

PMID29713658
PMCPMC5920535

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.