Trial reportBioMed research international2018
A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma.
Trial report in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07709819 (A Nanoscopic Second Look Into the Knee Joint, What Have We Learned?), which is not on this map. Cited by 63 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Nanoscopic Second Look Into the Knee Joint, What Have We Learned?
Who cites it
63 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Efficacy of platelet-rich plasma in meniscal repair surgery: a systematic review of randomized controlled trials.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024Pooled it
- No evidence in support of arthroscopic partial meniscectomy in adults with degenerative and nonobstructive meniscal symptoms: a level I evidence-based systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies.Journal of orthopaedic surgery and research · 2022Pooled it
- Biological augmentation of meniscal repair: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Platelet-rich plasma (PRP) augmentation does not result in more favourable outcomes in arthroscopic meniscal repair: a meta-analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022Pooled it
- Clinical efficacy of platelet-rich plasma as adjuvant therapy in patients undergoing arthroscopic repair of meniscal injury.The Journal of international medical research · 2020Pooled it
- Arthroscopic meniscal surgery: a national society treatment guideline and consensus statement.The bone & joint journal · 2019Guideline
- Differential Therapeutic Efficacy of Autologous Platelet-Rich Plasma at Varying Concentrations in the Treatment of Deep Second-Degree Burn and Its Underlying Molecular Mechanisms.Journal of cosmetic dermatology · 2026Trial
- Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study.International journal of molecular sciences · 2019Trial
- Efficacy of Intra-Articular Injection of Platelet-Rich Plasma and Growth Factor Concentrate in Degenerative Meniscal Lesions.Journal of orthopaedic case reports · 2026Article
- Systematic reviews in PRP-augmented meniscal repair have limited methodological quality: A systematic overview.Journal of experimental orthopaedics · 2026Article
- Failure rates increase over time and are higher following medial arthroscopic bucket-handle meniscal repair: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2026Review
- Platelet-rich plasma facilitates earlier functional recovery and return to sport in traumatic meniscal repair: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Short-term outcomes of two PRP-based treatment protocols for Stoller grade I-II meniscal lesions: serial ultrasound-guided perimeniscal PRP injections versus arthroscopic management with a single intra-operative intra-articular PRP injection.BMC musculoskeletal disorders · 2026Article
- Fibrin Clot Augmented Meniscal Repair: A Technique to Enhance Healing After Bucket Handle Medial Meniscus Repair.Cureus · 2026Article
- Rethinking meniscal repair in patients over 40: Extending the boundaries of joint preservation.World journal of methodology · 2026Review
- Biologic Augmentation for Meniscus Repair: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- A clinical practice review: augmentation of meniscoligamentous structures for primary prevention of knee joint deterioration.Annals of joint · 2026Review
- The Impact of Lower Extremity Mechanical Axis Alignment on the Success of Platelet-Rich Plasma Injections in Knee Osteoarthritis Patients.Orthopaedic surgery · 2025Article
- Short-Term Outcomes After Transtibial Repair of Medial Meniscus Posterior Root Tears: A Case Series.Journal of clinical medicine · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study aimed to investigate the effectiveness and safety of platelet-rich plasma (PRP) application in arthroscopic repair of complete vertical tear of meniscus located in the red-white zone.
methodsThis single center, prospective, randomized, double-blind, placebo-controlled, parallel-arm study included 37 patients with complete vertical meniscus tears. Patients received an intrarepair site injection of either PRP or sterile 0.9% saline during an index arthroscopy. The primary endpoint was the rate of meniscus healing in the two groups. The secondary endpoints were changes in the International Knee Documentation Committee (IKDC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and analog scale (VAS) in the two groups at 42 months.
resultsAfter 18 weeks, the meniscus healing rate was significantly higher in the PRP-treated group than in the control group (85% versus 47%,
conclusionsThe findings of this study indicate that PRP augmentation in meniscus repair results in improvements in both meniscus healing and functional outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.