Evidence map›Paper›PMID 29713548›Full record

ReviewArab journal of urology2018

Spermatogonial stem cell transplantation and male infertility: Current status and future directions.

Connor M Forbes, Ryan Flannigan, Peter N Schlegel

Open access · diamondAbstract readReview
In one paragraph

Review in Arab journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
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  12. Review
  13. Is It Possible to Treat Infertility with Stem Cells?Reproductive sciences (Thousand Oaks, Calif.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Connor M ForbesDepartment of Urology, University of British Columbia, Vancouver, British Columbia, Canada.
Ryan FlanniganDepartment of Urology, Weill Cornell Medicine, New York, NY, USA.
Peter N SchlegelDepartment of Urology, Weill Cornell Medicine, New York, NY, USA.
Cornell University · USUniversity of British Columbia · CAWeill Cornell Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. MATERIALS AND

methodsWe performed a search for publications addressing spermatogonial stem cell transplantation in the treatment of male infertility. The search engines PubMed and Google Scholar were used from 1990 to 2017. Search terms were relevant for spermatogonial stem cell therapies. Titles of publications were screened for relevance; abstracts were read, if related and full papers were reviewed for directly pertinent original research.

resultsIn all, 58 papers were found to be relevant to this review, and were included in appropriate subheadings. This review discusses the various techniques that SSCs are being investigated to treat forms of male infertility.

conclusionsEvidence does not yet support clinical application of SSCs in humans. However, significant progress in the

Indexed as

AllograftART, assisted reproductive technologiesBcl6b, B-Cell CLL/Lymphoma 6BBMP4, bone morphogenetic protein 4CD(24)(34), cluster of differentiation (24)(34)c-Kit, KIT Proto-oncogene receptor tyrosine kinaseFertility preservationFGF2, Fibroblast growth factor 2FISH, fluorescence in situ hybridisationGDNF, glial cell line-derived neurotrophic factorICSI, intracytoplasmic sperm injectionID4, inhibitor of differentiation 4KS, Klinefelter syndromeMale infertilityNon-obstructive azoospermiaOnco-fertilityPGC, primordial germ cellsPLZF, promyelocytic leukaemia zinc fingerPRISMA, Preferred Reporting Items for Systematic Reviews and Meta-AnalysesRA(R), retinoic acid (receptor)SPG, spermatogoniaSSC, spermatogonial stem cellStem cell therapyStra8, stimulated by RA 8ZBTB, zinc finger and broad complex/Tramtrack/bric-a-brac

Identifiers

PMID29713548
PMCPMC5922182
OpenAlexW2779246035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.