ArticleArab journal of urology2018
Update on the proteomics of male infertility: A systematic review.
Article in Arab journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Proteomic Landscape of Spermatozoa Under Inflammatory and Oxidative Injury: Molecular Mechanisms and Clinical Translation.Antioxidants (Basel, Switzerland) · 2026Review
- USP2 Attenuates Spermatogenic Cell Apoptosis Via PINK1/Parkin-Dependent Mitophagy in Varicocoele: A Functional Study.Andrology · 2026Article
- A Comprehensive Mass Spectrometry-Based Proteomic Dataset of Human Spermatozoa.Scientific data · 2025Article
- Protein profile of spermatozoa and seminal plasma based on molecular weight in four phenotypes ofOpen veterinary journal · 2025Article
- Seminal plasma PGK2 serves as a predictive biomarker for post-varicocelectomy sperm motility improvement in varicocele subjects.Translational andrology and urology · 2025Article
- Proteomics and Metabolomics in Varicocele-Associated Male Infertility: Advancing Precision Diagnostics and Therapy.Journal of clinical medicine · 2024Review
- Proteomic Insights into Seminal Plasma and Spermatozoa Proteins of Small-Spotted Catsharks,Animals : an open access journal from MDPI · 2024Article
- Bringing proteomics to bear on male fertility: key lessons.Expert review of proteomics · 2024Review
- Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.The world journal of men's health · 2024Article
- Age-dependent variations in proteomic characteristics of spermatozoa in Simmental bull.Frontiers in veterinary science · 2024Article
- The Application of Ejaculate-Based Shotgun Proteomics for Male Infertility Screening.Biomedicines · 2023Article
- Exploring the Potential of Plant Bioactive Compounds against Male Infertility: An In Silico and In Vivo Study.Molecules (Basel, Switzerland) · 2023Article
- Seminal plasma protein profiles and testosterone levels as biomarker semen quality of candidate Madura bulls.Journal of advanced veterinary and animal research · 2023Article
- Development and validation of a conventional in vitro total fertilization failure prediction model.Journal of assisted reproduction and genetics · 2023Article
- Mass Spectrometry-Based Untargeted Approaches to Reveal Diagnostic Signatures of Male Infertility in Seminal Plasma: A New Laboratory Perspective for the Clinical Management of Infertility?International journal of molecular sciences · 2023Review
- Molecular Interactions Associated with Oxidative Stress-Mediated Male Infertility: Sperm and Seminal Plasma Proteomics.Advances in experimental medicine and biology · 2022Review
- Aldose Reductase B1 in Pig Sperm Is Related to Their Function and Fertilizing Ability.Frontiers in endocrinology · 2022Article
- An In-Depth Bibliometric Analysis and Current Perspective on Male infertility Research.The world journal of men's health · 2021Article
- MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility.Life science alliance · 2021Article
- Proteomic Profiling of Seminal Plasma Proteins in Varicocele Patients.The world journal of men's health · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the role of differentially expressed proteins as a resource for potential biomarker identification of infertility, as male infertility is of rising concern in reproductive medicine and evidence pertaining to its aetiology at a molecular level particularly proteomic as spermatozoa lack transcription and translation. Proteomics is considered as a major field in molecular biology to validate the target proteins in a pathophysiological state. Differential expression analysis of sperm proteins in infertile men and bioinformatics analysis offer information about their involvement in biological pathways. MATERIALS AND
methodsLiterature search was performed on PubMed, Medline, and Science Direct databases using the keywords 'sperm proteomics' and 'male infertility'. We also reviewed the relevant cross references of retrieved articles and included them in the review process. Articles written in any language other than English were excluded.
resultsOf 575 articles identified, preliminary screening for relevant studies eliminated 293 articles. At the next level of selection, from 282 studies only 80 articles related to male infertility condition met the selection criteria and were included in this review.
conclusionIn this molecular era, sperm proteomics has created a platform for enhanced understanding of male reproductive physiology as a potential tool for identification of novel protein biomarkers related to sperm function in infertile men. Therefore, it is believed that proteomic biomarkers can overcome the gaps in information from conventional semen analysis that are of limited clinical utility.
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