ArticleArab journal of urology2018
A systematic review on the genetics of male infertility in the era of next-generation sequencing.
Article in Arab journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The genetic insights of sporadic male infertility: a systematic review of WES and WGS studies (2014-2024).Human genomics · 2026Pooled it
- Genetic alterations in poor-quality individually selected sperm highlight candidate biomarkers for male subfertility.Scientific reports · 2026Article
- Next-Generation Sequencing Infertility Panel in Turkey: First Results.Balkan journal of medical genetics : BJMG · 2024Article
- Circular RNAs: novel noncoding players in male infertility.Hereditas · 2024Review
- Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives.Genes · 2024Review
- Identification of novel candidate genes associated with meiotic aneuploidy in human embryos by whole-exome sequencing.Journal of assisted reproduction and genetics · 2023Observational
- The infertile individual analysis based on whole-exome sequencing in chinese multi-ethnic groups.Genes & genomics · 2023Article
- Profiling the male germline genome to unravel its reproductive potential.Fertility and sterility · 2023Article
- Bi-allelic variants in DNAH10 cause asthenoteratozoospermia and male infertility.Journal of assisted reproduction and genetics · 2022Article
- Targeted next-generation sequencing panel screening of 668 Chinese patients with non-obstructive azoospermia.Journal of assisted reproduction and genetics · 2021Article
- Defining new genetic etiologies of male infertility: progress and future prospects.Translational andrology and urology · 2021Review
- Genetic basis of acephalic spermatozoa syndrome, and intracytoplasmic sperm injection outcomes in infertile men: a systematic scoping review.Journal of assisted reproduction and genetics · 2021Article
- Whole-Exome Sequencing Analysis of Human Semen Quality in Russian Multiethnic Population.Frontiers in genetics · 2021Article
- Current updates and future perspectives in the evaluation of azoospermia: A systematic review.Arab journal of urology · 2021Article
- Non-obstructive azoospermia: current and future perspectives.Faculty reviews · 2021Review
- Clinical Evaluation of a Custom Gene Panel as a Tool for Precision Male Infertility Diagnosis by Next-Generation Sequencing.Life (Basel, Switzerland) · 2020Article
- Genetic disorders and male infertility.Reproductive medicine and biology · 2020Review
- Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.BMC biology · 2020Article
- Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel.Frontiers in endocrinology · 2020Article
- Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice.American journal of human genetics · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo identify the role of next-generation sequencing (NGS) in male infertility, as advances in NGS technologies have contributed to the identification of novel genes responsible for a wide variety of human conditions and recently has been applied to male infertility, allowing new genetic factors to be discovered. MATERIALS AND
methodsPubMed was searched for combinations of the following terms: 'exome', 'genome', 'panel', 'sequencing', 'whole-exome sequencing', 'whole-genome sequencing', 'next-generation sequencing', 'azoospermia', 'oligospermia', 'asthenospermia', 'teratospermia', 'spermatogenesis', and 'male infertility', to identify studies in which NGS technologies were used to discover variants causing male infertility.
resultsAltogether, 23 studies were found in which the primary mode of variant discovery was an NGS-based technology. These studies were mostly focused on patients with quantitative sperm abnormalities (non-obstructive azoospermia and oligospermia), followed by morphological and motility defects. Combined, these studies uncover variants in 28 genes causing male infertility discovered by NGS methods.
conclusionsMale infertility is a condition that is genetically heterogeneous, and therefore remarkably amenable to study by NGS. Although some headway has been made, given the high incidence of this condition despite its detrimental effect on reproductive fitness, there is significant potential for further discoveries.
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