Evidence map›Paper›PMID 29713475›Full record

ArticleOncology & hematology review2018

Exercise for Toxicity Management in Cancer-A Narrative Review.

Ian R Kleckner, Richard F Dunne, Matthew Asare, Calvin Cole, Fergal Fleming, Chunkit Fung, Po-Ju Lin, Karen M Mustian

Abstract read
In one paragraph

Article in Oncology & hematology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  5. The potential impact of exercise upon symptom burden in adolescents and young adults undergoing cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  6. Trial
  7. Effects of exercise on inflammation in patients receiving chemotherapy: a nationwide NCORP randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Trial
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  17. Improving the prediction of chemotherapy dose-limiting toxicity in colon cancer patients using an AI-CT-based 3D body composition of the entire L1-L5 lumbar spine.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ian R KlecknerUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Richard F DunneUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Matthew AsareUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Calvin ColeUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Fergal FlemingUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Chunkit FungUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Po-Ju LinUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Karen M MustianUniversity of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
UNIVERSITY OF ROCHESTER--CCOP RESEARCH BASEU10CA037420 · NCI · UNIVERSITY OF ROCHESTER · PI MORROW, GARY R · 1985 to 2014
$21.1M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
NCI NIH HHS R25 CA102618NCI NIH HHS U10 CA037420NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

Although the treatment of cancer is more effective now than ever, patients with cancer still face acute and chronic toxicities such as fatigue, cardiotoxicity, pain, cognitive impairment, and neurotoxicity. In this narrative review, we briefly discuss the use of exercise for toxicity management in patients with cancer, biological mechanisms underlying the toxicities and the effects of exercise, barriers that patients- especially underserved patients-face in adopting and adhering to exercise programs, and new technologies to overcome barriers to exercise. Our conclusions and clinical suggestions are: (1) exercise is safe and effective for treating many toxicities; (2) patients can benefit from a variety of exercise modalities (e.g., walking, cycling, resistance bands, yoga); (3) exercise should be started as soon as possible, even before treatments begin; (4) exercise should be continued as long as possible, as a lifestyle; and (5) barriers to exercise should be identified and addressed, (e.g., continually encouraging patients to exercise, using mobile technology, advocating for safe communities that encourage active lifestyles). Future research should inform definitive clinical guidelines for the use of exercise to ameliorate toxicities from cancer and its treatment.

Indexed as

disparitiesexercisemechanismmHealthSide effectsTai Chitoxicitiesyoga

Identifiers

PMID29713475
PMCPMC5922767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.