ArticleClinical epigenetics2018
Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study.
Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
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Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Pooled it
- The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis.Clinical epigenetics · 2019Pooled it
- Trial
- Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health.Circulation research · 2021Trial
- The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Social media use duration and epigenetic aging among U.S. adults in the MIDUS refresher study.PLOS digital health · 2026Article
- Interferon-related inflammaging links epigenetic age acceleration to multimorbidity.Cell genomics · 2026Article
- Article
- The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study.Clinical epigenetics · 2026Article
- Lower diet quality accelerates DNA methylation-based age.GeroScience · 2026Article
- Longitudinal association of circulating inflammatory biomarkers with epigenetic ageing in the Young Finns Study.Scientific reports · 2026Article
- Association of plasma metabolites with epigenetic age acceleration: a two-sample Mendelian randomization study.Biogerontology · 2025Article
- Relationship stress and epigenetic age acceleration among older U.S. adults in the Midlife in the United States study.Epigenomics · 2025Article
- Exploring causal relationships between epigenetic age acceleration and Alzheimer's disease: a bidirectional Mendelian randomization study.Clinical epigenetics · 2025Article
- Age and Inflammation: Insights on "Age Three Ways" from Midlife in the United States Study.Brain, behavior, and immunity · 2025Article
- Article
- Epigenetic clocks and inflammaging: pitfalls caused by ignoring cell-type heterogeneity.GeroScience · 2025Article
- Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes.Clinical epigenetics · 2025Article
- Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database.Frontiers in physiology · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Background: Recently, epigenetic age acceleration-or older epigenetic age in comparison to chronological age-has been robustly associated with mortality and various morbidities. However, accelerated epigenetic aging has not been widely investigated in relation to inflammatory or metabolic markers, including postprandial lipids. Methods: We estimated measures of epigenetic age acceleration in 830 Caucasian participants from the Genetics Of Lipid Lowering Drugs and diet Network (GOLDN) considering two epigenetic age calculations based on differing sets of 5'-Cytosine-phosphate-guanine-3' genomic site, derived from the Horvath and Hannum DNA methylation age calculators, respectively. GOLDN participants underwent a standardized high-fat meal challenge after fasting for at least 8 h followed by timed blood draws, the last being 6 h postmeal. We used adjusted linear mixed models to examine the association of the epigenetic age acceleration estimate with fasting and postprandial (0- and 6-h time points) low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels as well as five fasting inflammatory markers plus adiponectin. Results: Both DNA methylation age estimates were highly correlated with chronological age ( Conclusions: Our study demonstrates that epigenetic age acceleration in blood relates to inflammatory biomarkers and certain lipid classes in Caucasian individuals of the GOLDN study. Future studies should consider epigenetic age acceleration in other tissues and extend the analysis to other ethnic groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.