Evidence map›Paper›PMID 29713153›Full record

Trial reportInternational journal of chronic obstructive pulmonary disease

Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure.

Line Hust Storgaard, Hans-Ulrich Hockey, Birgitte Schantz Laursen, Ulla Møller Weinreich

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 80 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 7 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03772626 naunknown statusnot on this map

The Feasibility and Efficacy of Heated Humidified Nasal Cannula (AIRVOTM) in Hospital and at Home - An Open-Label, Non-Randomized Pilot Study.

TypeinterventionalSponsorMcMaster UniversityRan2019 to 2022Enrolled30ConditionsCOPD ExacerbationArmsHeated Humidified High-flow Nasal Cannula
NCT07065799 narecruitingnot on this map

Respiratory Strategies in COPD Patients With Persistent Hypercapnia Following Exacerbation: A Multicenter, Non-inferiority, Randomized, Crossover Study

TypeinterventionalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2024 to 2028Enrolled31ConditionsCOPD, Hypercapnia, Exacerbation CopdArmsGroup 1: NHF/LTOT, Group 2: HMV/LTOT
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 7 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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  14. Hospital Cost Savings for Sequential COPD Patients Receiving Domiciliary Nasal High Flow Therapy.International journal of chronic obstructive pulmonary disease · 2022
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  17. Development in PaCOBMJ open respiratory research · 2020
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Line Hust StorgaardDepartment of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark.
Hans-Ulrich HockeyBiometrics Matters Limited, Hamilton, New Zealand.
Birgitte Schantz LaursenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Ulla Møller WeinreichDepartment of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark.
Aalborg University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated the long-term effects of humidified high-flow nasal cannula (HFNC) in COPD patients with chronic hypoxemic respiratory failure treated with long-term oxygen therapy (LTOT). PATIENTS AND

methodsA total of 200 patients were randomized into usual care ± HFNC. At inclusion, acute exacerbation of COPD (AECOPD) and hospital admissions 1 year before inclusion, modified Medical Research Council (mMRC) score, St George's Respiratory Questionnaire (SGRQ), forced expiratory volume in 1 second (FEV

resultsThe average daily use of HFNC was 6 hours/day. The HFNC group had a lower AECOPD rate (3.12 versus 4.95/patient/year,

conclusionHFNC treatment reduced AECOPD, hospital admissions and symptoms in COPD patients with hypoxic failure.

Indexed as

CannulaAgedBlood Gas AnalysisCatheterizationCause of DeathChronic DiseaseDenmarkDisease ProgressionEquipment DesignExercise ToleranceFemaleForced Expiratory VolumeHealth StatusHumansHypoxiaLung6-minute walk test6MWTAECOPDCOPDexacerbationHFNChigh-flow heated and humidified oxygenmMRC scoremodified Medical Research Council score

Identifiers

PMID29713153
PMCPMC5909797
OpenAlexW2796492789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.