ArticleWorld journal of gastroenterology2018
High tacrolimus intra-patient variability is associated with graft rejection, and
Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Tacrolimus dosing in liver transplant recipients using phenotypic personalized medicine: A phase 2 randomized clinical trial.Nature communications · 2025Trial
- Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients.Scientific reports · 2021Trial
- Comparison in Patients' Adherence, Adverse Effects, and Clinical Outcomes Among Liver Transplant Recipients Using Immediate-Release Tacrolimus (PrografArchives of Iranian medicine · 2026Observational
- Chronic High Epstein-Barr Viral Load Carriage Is Positively Correlated With Tacrolimus Intra-Patient Variability After Pediatric Liver Transplantation.Journal of medical virology · 2025Article
- Association between the Stanford Integrated Psychosocial Assessment for Transplant and 1-year medication nonadherence after living kidney transplantation.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Impact of Intrapatient Immunosuppression Variability in Liver Transplantation Outcomes: A Systematic Review and Meta-analysis.Transplantation direct · 2024Article
- Machine-learning model to predict the tacrolimus concentration and suggest optimal dose in liver transplantation recipients: a multicenter retrospective cohort study.Scientific reports · 2024Article
- High intra-patient variability of tacrolimus within post-operative 1 month predicted worse 1-year outcomes in pediatric liver transplant recipients.European journal of clinical pharmacology · 2024Article
- A Feasibility Open-Labeled Clinical Trial Using a Second-Generation Artificial-Intelligence-Based Therapeutic Regimen in Patients with Gaucher Disease Treated with Enzyme Replacement Therapy.Journal of clinical medicine · 2024Article
- Erratic tacrolimus levels at 6 to 12 months post-lung transplant predicts poor outcomes.JHLT open · 2024Article
- Article
- Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation.World journal of transplantation · 2023Review
- Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1.Microbiome · 2023Article
- Impact of Early Intrapatient Variability of Tacrolimus Concentrations on the Risk of Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation Using High-Dose Post-Transplant Cyclophosphamide.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Clinical association between tacrolimus intra-patient variability and liver transplantation outcomes in patients with and without hepatocellular carcinoma.Scientific reports · 2022Article
- Insights into the Pharmacogenetics of Tacrolimus Pharmacokinetics and Pharmacodynamics.Pharmaceutics · 2022Review
- Next-Generation Personalized Medicine: Implementation of Variability Patterns for Overcoming Drug Resistance in Chronic Diseases.Journal of personalized medicine · 2022Review
- A new method to calculate intra-patient variability in tacrolimus concentrations.British journal of clinical pharmacology · 2022Article
- High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation.Clinical and translational science · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of tacrolimus intra-patient variability (IPV) in adult liver-transplant recipients.
methodsWe retrospectively assessed tacrolimus variability in a cohort of liver-transplant recipients and analyzed its effect on the occurrence of graft rejection and
resultsTwenty-two patients (18.5%) experienced at least one acute-rejection episode (BPAR). Predictive factors for a BPAR were a tacrolimus IPV of > 35% [OR = 3.07 95%CI (1.14-8.24),
conclusionTacrolimus-IPV could be a useful tool to identify patients with a greater risk of graft rejection and of developing a
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