ArticleNature chemistry2018
Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly.
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Design of light- and chemically responsive protein assemblies through host-guest interactions.Chem · 2025Article
- Assembly and Functionality of 2D Protein Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device.Nature communications · 2024Article
- Heme-substituted protein assembly bridged by synthetic porphyrin: achieving controlled configuration while maintaining rotational freedom.RSC advances · 2024Article
- Lipidation Alters the Structure and Hydration of Myristoylated Intrinsically Disordered Proteins.Biomacromolecules · 2023Article
- Protein Assembly by Design.Chemical reviews · 2021Review
- Design of metal-mediated protein assemblies via hydroxamic acid functionalities.Nature protocols · 2021Article
- Ion-dependent protein-surface interactions from intrinsic solvent response.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Nucleation of protein mesocrystals via oriented attachment.Nature communications · 2021Article
- Article
- Structural resolution of switchable states of a de novo peptide assembly.Nature communications · 2021Article
- Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry.Nature communications · 2021Article
- Article
- Role of Entropy in Colloidal Self-Assembly.Entropy (Basel, Switzerland) · 2020Review
- Assembly of a patchy protein into variable 2D lattices via tunable multiscale interactions.Nature communications · 2020Article
- Modulation of the Self-Assembly of π-Amphiphiles in Water from Enthalpy- to Entropy-Driven by Enwrapping Substituents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors.ACS synthetic biology · 2019Article
- Protein Assemblies: Nature-Inspired and Designed Nanostructures.Biomacromolecules · 2019Review
- Supercharging enables organized assembly of synthetic biomolecules.Nature chemistry · 2019Article
- Construction of supramolecular nanotubes from protein crystals.Chemical science · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
De novo design and construction of stimuli-responsive protein assemblies that predictably switch between discrete conformational states remains an essential but highly challenging goal in biomolecular design. We previously reported synthetic, two-dimensional protein lattices self-assembled via disulfide bonding interactions, which endows them with a unique capacity to undergo coherent conformational changes without losing crystalline order. Here, we carried out all-atom molecular dynamics simulations to map the free-energy landscape of these lattices, validated this landscape through extensive structural characterization by electron microscopy and established that it is predominantly governed by solvent reorganization entropy. Subsequent redesign of the protein surface with conditionally repulsive electrostatic interactions enabled us to predictably perturb the free-energy landscape and obtain a new protein lattice whose conformational dynamics can be chemically and mechanically toggled between three different states with varying porosities and molecular densities.
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