ArticleScientific reports2018
Three-dimensional computational model simulating the fracture healing process with both biphasic poroelastic finite element analysis and fuzzy logic control.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regulatory Adoption of AI, ML, Computational Modeling & Simulation in In-Silico Clinical Trials for Medical Devices: A Systematic Review.Therapeutic innovation & regulatory science · 2026Pooled it
- Staged screw removal in external plate fixation for distal tibial fractures: a finite element study on adaptive biomechanics.Scientific reports · 2026Article
- Biomechanics of Osseointegration of a Dental Implant in the Mandible Under Shock Wave Therapy: In Silico Study.Materials (Basel, Switzerland) · 2024Article
- A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents.Scientific reports · 2024Article
- Three-Dimensional Computational Model Simulating the Initial Callus Growth during Fracture Healing in Long Bones: Application to Different Fracture Types.Bioengineering (Basel, Switzerland) · 2023Article
- COMMBINI: an experimentally-informed COmputational Model of Macrophage dynamics in the Bone INjury Immunoresponse.Frontiers in immunology · 2023Article
- The osteogenetic activities of mesenchymal stem cells in response to Mg2+ ions and inflammatory cytokines: a numerical approach using fuzzy logic controllers.PLoS computational biology · 2022Article
- A 3DFrontiers in bioengineering and biotechnology · 2022Article
- Numerical Modeling of Shockwave Treatment of Knee Joint.Materials (Basel, Switzerland) · 2021Article
- Design and Mechanical Properties Verification of Gradient Voronoi Scaffold for Bone Tissue Engineering.Micromachines · 2021Article
- Fuzzy PID Control for Respiratory Systems.Journal of healthcare engineering · 2021Article
- TowardsFrontiers in bioengineering and biotechnology · 2021Review
- [Numerical simulation of fracture healing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- 3D Printed Wavy Scaffolds Enhance Mesenchymal Stem Cell Osteogenesis.Micromachines · 2019Article
- Optimization of Bone Scaffold Porosity Distributions.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A dynamic model regulated by both biphasic poroelastic finite element analysis and fuzzy logic control was established. Fuzzy logic control was an easy and comprehensive way to simulate the tissue differentiation process, and it is convenient for researchers and medical experts to communicate with one another to change the fuzzy logic rules and improve the simulation of the tissue differentiation process. In this study, a three-dimensional fracture healing model with two different interfragmentary movements (case A: 0.25 mm and case B: 1.25 mm) was analysed with the new set-up computational model. As the healing process proceeded, both simulated interfragmentary movements predicted a decrease and the time that the decrease started for case B was later than that for case A. Compared with experimental results, both cases corresponded with experimental data well. The newly established dynamic model can simulate the healing process under different mechanical environments and has the potential to extend to the multiscale healing model, which is essential for reducing the animal experiments and helping to characterise the complex dynamic interaction between tissue differentiations within the callus region.
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Registered trials
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