ArticleScientific reports2018
A low voltage nanopipette dielectrophoretic device for rapid entrapment of nanoparticles and exosomes extracted from plasma of healthy donors.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Matrix Stiffness Modulates 3D Spheroid-Derived Extracellular Vesicle Profiles and Discovery of Piezo1 Cargo.Cellular and molecular bioengineering · 2026Article
- Stage-Specific Molecular Cargo of Schwann Cell-Derived Extracellular Vesicles is Associated With Peripheral Nerve Repair.Journal of extracellular biology · 2026Article
- Lipid Membrane-Coated Nanopipettes for Enhanced Resistive Pulse Sensing of Exosomes.ACS applied materials & interfaces · 2026Article
- Isolation methods of exosomes derived from dental stem cells.International journal of oral science · 2025Review
- Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells.Biosensors · 2024Review
- Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes as Nanomedicine for Peripheral Nerve Injury.International journal of molecular sciences · 2024Review
- A Review of Research Progress in Microfluidic Bioseparation and Bioassay.Micromachines · 2024Review
- Biomechanics of circulating cellular and subcellular bioparticles: beyond separation.Cell communication and signaling : CCS · 2024Review
- Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon Cancer Diagnosis.Sensors (Basel, Switzerland) · 2023Review
- Rapid purification and multiparametric characterization of circulating small extracellular vesicles utilizing a label-free lab-on-a-chip device.Scientific reports · 2023Article
- Sub-100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces.Micromachines · 2022Article
- A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties.Biosensors · 2022Article
- A label-free and low-power microelectronic impedance spectroscopy for characterization of exosomes.PloS one · 2022Article
- Recent developments in isolating methods for exosomes.Frontiers in bioengineering and biotechnology · 2022Review
- The latest advances on nonlinear insulator-based electrokinetic microsystems under direct current and low-frequency alternating current fields: a review.Analytical and bioanalytical chemistry · 2022Review
- Microscale nonlinear electrokinetics for the analysis of cellular materials in clinical applications: a review.Mikrochimica acta · 2021Review
- Exosome isolation using nanostructures and microfluidic devices.Biomedical materials (Bristol, England) · 2021Review
- An Electrokinetically-Driven Microchip for Rapid Entrapment and Detection of Nanovesicles.Micromachines · 2020Article
- Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications.Sensors (Basel, Switzerland) · 2020Review
- Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics.Theranostics · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An insulator-based dielectrophoresis (iDEP) is a label-free method that has been extensively utilized for manipulation of nanoparticles, cells, and biomolecules. Here, we present a new iDEP approach that can rapidly trap nanoparticles at the close proximity of a glass nanopipette's tip by applying 10 V/cm direct current (DC) across the pipette's length. The trapping mechanism was systemically studied using both numerical modeling and experimental observations. The results showed that the particle trapping was determined to be controlled by three dominant electrokinetic forces including dielectrophoretic, electrophoretic and electroosmotic force. Furthermore, the effect of the ionic strength, the pipette's geometry, and the applied electric field on the entrapment efficiency was investigated. To show the application of our device in biomedical sciences, we demonstrated the successful entrapment of fluorescently tagged liposomes and unlabeled plasma-driven exosomes from the PBS solution. Also, to illustrate the selective entrapment capability of our device, 100 nm liposomes were extracted from the PBS solution containing 500 nm polystyrene particles at the tip of the pipette as the voltage polarity was reversed.
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