Evidence map›Paper›PMID 29712925›Full record

ArticleNature communications2018

The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.

Eunjeong Kwon, Kristina Todorova, Jun Wang, Rastislav Horos, Kevin K Lee, Victor A Neel, Gian Luca Negri, Poul H Sorensen, Sam W Lee, Matthias W Hentze and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 110 citations in OpenAlex.

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  14. RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation.Proceedings of the National Academy of Sciences of the United States of America · 2025
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Eunjeong KwonCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Kristina TodorovaCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Jun WangCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Rastislav HorosEuropean Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117, Heidelberg, Germany.
Kevin K LeeCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Victor A NeelDepartment of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Gian Luca NegriDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V5Z 1L3, Canada.
Poul H SorensenDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V5Z 1L3, Canada.
Sam W LeeCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Matthias W HentzeEuropean Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117, Heidelberg, Germany.
Anna MandinovaCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA. amandinova@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · USEuropean Molecular Biology Laboratory · DEUniversity of British Columbia · CABroad Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integrity of stratified epithelia depends on the ability of progenitor cells to maintain a balance between proliferation and differentiation. While much is known about the transcriptional pathways underlying progenitor cells' behavior in the epidermis, the role of posttranscriptional regulation by mRNA binding proteins-a rate-limiting step in sculpting the proteome-remains poorly understood. Here we report that the RNA binding protein YBX1 (Y-box binding protein-1) is a critical effector of progenitors' function in the epidermis. YBX1 expression is restricted to the cycling keratinocyte progenitors in vivo and its genetic ablation leads to defects in the architecture of the skin. We further demonstrate that YBX1 negatively controls epidermal progenitor senescence by regulating the translation of a senescence-associated subset of cytokine mRNAs via their 3' untranslated regions. Our study establishes YBX1 as a posttranscriptional effector required for maintenance of epidermal homeostasis.

Indexed as

RNA Processing, Post-Transcriptional3' Untranslated RegionsAnimalsCell CycleCell DifferentiationCell ProliferationCellular SenescenceChemokine CXCL1Embryo, MammalianEpidermal CellsEpidermisHumansInterleukin-8KeratinocytesMicePrimary Cell Culture3' Untranslated RegionsChemokine CXCL1CXCL1 protein, humanInterleukin-8RNA, Small InterferingTranscription FactorsY-Box-Binding Protein 1YBX1 protein, humanYbx1 protein, mouse

Identifiers

PMID29712925
PMCPMC5928080
OpenAlexW2806083865

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.