ArticleClinical and translational gastroenterology2018
Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer.
Article in Clinical and translational gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 20 citations in OpenAlex.
- Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope.Analytical chemistry · 2025Article
- An Unexpected Case of Somatic Mosaicism of the Dutch p16-Case reports in genetics · 2025Article
- Contrast-enhanced CT radiomics features to preoperatively identify differences between tumor and proximal tumor-adjacent and tumor-distant tissues of resectable esophageal squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions.Oral oncology · 2022Article
- Screening for head and neck tumors in patients with esophageal squamous cell carcinoma and vice versa: a nationwide survey among medical specialists.Endoscopy international open · 2022Article
- Characterizing factors influencing calibration and optical property determination in quantitative reflectance spectroscopy to improve standardization.Journal of biomedical optics · 2022Article
- Early Upper Aerodigestive Tract Cancer Detection Using Electron Microscopy to Reveal Chromatin Packing Alterations in Buccal Mucosa Cells.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2021Article
- Bimodal multispectral imaging system with cloud-based machine learning algorithm for real-time screening and detection of oral potentially malignant lesions and biopsy guidance.Journal of biomedical optics · 2021Article
- Experimental validation of a recently developed model for single-fiber reflectance spectroscopy.Journal of biomedical optics · 2021Article
- Subdiffuse scattering and absorption model for single fiber reflectance spectroscopy.Biomedical optics express · 2020Article
- Clinicopathological features and prognosis of patients with esophageal cancer as the second primary cancer: a large population-based analysis using the SEER program [2000-2015].Translational cancer research · 2020Article
- Subdiffuse scattering model for single fiber reflectance spectroscopy.Journal of biomedical optics · 2020Article
- Towards the Optical Detection of Field Cancerization in the Buccal Mucosa of Patients with Lung Cancer.Translational oncology · 2019Article
- Optical pre-screening for laryngeal cancer using reflectance spectroscopy of the buccal mucosa.Biomedical optics express · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEsophageal cancer is an increasingly common type of neoplasm with a very poor prognosis. This prognosis could improve with more early tumor detection. We have previously shown that we can use an optical spectroscopy to detect field cancerization in the buccal mucosa of patients with laryngeal cancer. The aim of this prospective study was to investigate whether we could detect field cancerization of buccal mucosa of patients with esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).
methodsOptical measurements were performed in vivo using a novel optical technique: multidiameter single-fiber reflectance (MDSFR) spectroscopy. MDSFR spectra were acquired by a handheld probe incorporating three fiber diameters. Multiple absorption and scattering parameters that are related to the physiological and ultrastructural properties of the buccal mucosa were derived from these spectra. A linear discriminant analysis of the parameters was performed to create a combined biomarker σ to discriminate oncologic from non-oncologic patients.
resultsTwelve ESCC, 12 EAC, and 24 control patients were included in the study. The median value of our biomarker σ was significantly higher in patients with ESCC (2.07 [1.93-2.10]) than control patients (1.86 [1.73-1.95], p = 0.022). After cross-validation σ was able to identify ESCC patients with a sensitivity of 66.7% and a specificity of 70.8%. There were no significant differences between the EAC group and the control group.
conclusionField cancerization in the buccal mucosa can be detected using optical spectroscopy in ESCC patients. This may be the first step towards non-invasive ESCC cancer screening.
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