Evidence map›Paper›PMID 29712884›Full record

ArticleClinical science (London, England : 1979)2018

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease.

Judith N Lezutekong, Anish Nikhanj, Gavin Y Oudit

Abstract readComment
PubMed Publisher
In one paragraph

Article in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

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  12. Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Judith N LezutekongDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Anish NikhanjDivision of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Gavin Y OuditDivision of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada gavin.oudit@ualberta.ca.
University of Alberta · CA

Funding

CIHR 855332
6 · The paper itself

Abstract

The main function of the intestinal barrier is to regulate the absorption of nutrients, electrolytes, and water from the lumen into circulation and to prevent the entry of pathogenic microorganisms and toxic luminal substances. To maintain this function, an ideal microbiota balance is required and gut microbiota are critical for the intestinal epithelial barrier dysfunction and for the maintenance of physiological homeostasis. There is a demonstrable link between dysbiosis and intestinal dysfunction and diseases such as diabetes, obesity, and cardiovascular disease. However, links amongst gut pathology, microbial ecology, and blood pressure remain elusive. In a recent issue of

Indexed as

Cardiovascular DiseasesGastrointestinal MicrobiomeHypertensionDysbiosisHumansIntestinesangiotensin IIhypertensionmicrobiotapatients

Identifiers

PMID29712884
OpenAlexW2803036722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.