ArticleClinical science (London, England : 1979)2018
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Open access · greenAbstract readConference Proceedings
In one paragraph
Article in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- MRI signatures associated with active ischemia and disease severity in cerebral small vessel disease.Neuroimage. Reports · 2025Article
- The role of multimorbidity in suspected dementia among elderly in Shanghai, China: a community-based cross-sectional study.Frontiers in psychiatry · 2025Article
- Article
- The ageing central nervous system in multiple sclerosis: the imaging perspective.Brain : a journal of neurology · 2024Review
- A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury.Nature neuroscience · 2024Article
- Nimodipine Protects Vascular and Cognitive Function in an Animal Model of Cerebral Small Vessel Disease.Stroke · 2024Article
- A bibliometric analysis of cerebral small vessel disease.Frontiers in aging neuroscience · 2024Article
- Brain Endothelial Cells Activate Neuroinflammatory Pathways in Response to Early Cerebral Small Vessel Disease (CSVD) Patients' Plasma.Biomedicines · 2023Article
- Microvascular arterial disease of the brain and the heart: a shared pathogenesis.QJM : monthly journal of the Association of Physicians · 2023Article
- The Venular Side of Cerebral Amyloid Angiopathy: Proof of Concept of a Neglected Issue.Biomedicines · 2023Review
- Does resveratrol improve cognition in humans? A scientometric study to an in-depth review.CNS neuroscience & therapeutics · 2023Review
- Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury.Research square · 2023Article
- Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.Molecular neurodegeneration · 2023Review
- Targeting lysyl-oxidase (LOX) may facilitate intramural periarterial drainage for the treatment of Alzheimer's disease.Cerebral circulation - cognition and behavior · 2023Review
- Collagen type IV as the link between arterial stiffness and dementia.American journal of translational research · 2023Review
- A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.Cerebral circulation - cognition and behavior · 2023Review
- The Role of DNA Methylation in Stroke Recovery.International journal of molecular sciences · 2022Review
- Coronary Microvascular Dysfunction.Journal of clinical medicine · 2020Review
- Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia.Acta neuropathologica communications · 2020Article
- ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 8 institutions in 3 countries.
Karen HorsburghCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K. Karen.horsburgh@ed.ac.uk.
Joanna M WardlawCentre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, U.K.
Tom van AgtmaelInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Stuart M AllanFaculty of Biology, Medicine and Health, University of Manchester, Manchester, U.K.
Mike L J AshfordSchool of Medicine, University of Dundee, Dundee, U.K.
Philip M BathStroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, U.K.
Rosalind BrownCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Jason BerwickDepartment of Psychology, University of Sheffield, Sheffield, U.K.
M Zameel CaderNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Roxana O CarareFaculty of Medicine, University of Southampton, Southampton, U.K.
John B DavisAlzheimer's Research UK Oxford Drug Discovery Institute, University of Oxford, Oxford, U.K.
Jessica DuncombeCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Tracy D FarrSchool of Life Sciences, Nottingham University, Nottingham, U.K.
Jill H FowlerCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Jozien GoenseInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, U.K.
Alessandra GranataDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, U.K.
Catherine N HallSchool of Psychology, University of Sussex, Brighton, U.K.
Atticus H HainsworthMolecular and Clinical Sciences Research Institute, St Georges University of London, London, U.K.
Adam HarveyInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Cheryl A HawkesFaculty of Science, Technology, Engineering & Mathematics, Open University, Milton Keynes, U.K.
Anne JoutelGenetics and Pathogenesis of Cerebrovascular Diseases, INSERM, Université Paris Diderot-Paris 7, Paris, France.
Rajesh N KalariaInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
Patrick G KehoeBristol Medical School, University of Bristol, Bristol, U.K.
Catherine B LawrenceFaculty of Biology, Medicine and Health, University of Manchester, Manchester, U.K.
Andy LockhartGSK (currently Heptares Therapeutics), U.K.
Seth LoveClinical Neurosciences, University of Bristol, Bristol, U.K.
Malcolm R MacleodCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.
I Mhairi MacraeInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, U.K.
Hugh S MarkusDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, U.K.
Chris McCabeInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, U.K.
Barry W McCollThe Roslin Institute & R(D)SVS, UK Dementia Research Institute, University of Edinburgh, Edinburgh, U.K.
Paul J MeakinDivision of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, U.K.
Alyson MillerInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Maiken NedergaardUniversity of Rochester Medical Center, Rochester, NY, USA and University of Copenhagen's Center of Basic and Translational Neuroscience, Copenhagen, Denmark.
Michael O'SullivanMater Centre for Neuroscience and Queensland Brain Institute, Brisbane, Australia.
Terry J QuinnInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Rikesh RajaniGenetics and Pathogenesis of Cerebrovascular Diseases, INSERM, Université Paris Diderot-Paris 7, Paris, France.
Lisa M SaksidaRobarts Research Institute, Western University, London, Ontario, Canada.
Colin SmithCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Kenneth J SmithDepartment of Neuroinflammation, UCL Institute of Neurology, London, U.K.
Rhian M TouyzInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Rebecca C TruemanSchool of Life Sciences, Nottingham University, Nottingham, U.K.
Tao WangFaculty of Biology, Medicine and Health, University of Manchester, Manchester, U.K.
Anna WilliamsMRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, U.K.
Steven C R WilliamsInstitute of Psychiatry, Kings College London, London, U.K.
Lorraine M WorkInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
University of Glasgow · GBUniversité Paris Cité · FRKing's College London · GBUniversity of Dundee · GBUniversity of Oxford · GBUniversity of Sheffield · GBUniversity of Southampton · GBWestern University · CA
Funding
Para-Vascular Basis of Small Vessel DiseaseR01NS100366 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2016 to 2020
$3.8MAge and AD related bottlenecks in glymphatic-lymphatic waste transportRF1AG057575 · NIA · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2017 to 2017
$3.2MCapillary hyperemia in white matter: Novel mechanistic insight and effect of hypertension and agingRF1NS110049 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN, WAN, JIANDI · 2018 to 2018
$2.9MGlymphatic function in a transgenic rat model of Alzheimer's diseaseR01AG048769 · NIA · UNIVERSITY OF ROCHESTER · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2014 to 2018
$1.4MBritish Heart Foundation PG/12/31/29527British Heart Foundation PG/15/44/31574British Heart Foundation PG/15/92/31813Chief Scientist Office CZB/4/517Medical Research Council G0400074Medical Research Council G0500247Medical Research Council G0502157Medical Research Council G0900652Medical Research Council G1100540Medical Research Council MC_PC_14095Medical Research Council MC_PC_16034Medical Research Council MR/K015397/1Medical Research Council MR/K017047/1Medical Research Council MR/L003384/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/M013553/1Medical Research Council MR/N003403/1Medical Research Council MR/R005567/1Medical Research Council MR/R014140/1National Centre for the Replacement, Refinement and Reduction of Animals in Research G0800701/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K001744/1NIA NIH HHS R01 AG048769NIA NIH HHS RF1 AG057575NINDS NIH HHS R01 NS100366NINDS NIH HHS RF1 NS110049
Abstract
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.
Indexed as
Translational Research, BiomedicalAnimalsCerebral Small Vessel DiseasesHumanscerebral vascular diseasedementia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.