ArticleReproduction (Cambridge, England)2018
Characterization of the collagen microstructural organization of human cervical tissue.
Article in Reproduction (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- The Role of Papaverine in the Molecular and Biomechanical Mechanisms of Cervical Ripening: A Narrative Review.International journal of molecular sciences · 2026Review
- Microstructure-Informed Hyper-Viscoelastic Model Capturing Soft Tissue Tensile Behavior Across Large Deformations.Journal of the mechanics and physics of solids · 2026Article
- Review
- Article
- Fatigue loading and volumetric microscopy demonstrate changes to the mouse cervix throughout and after pregnancy.Connective tissue research · 2025Article
- First-Order Speckle Statistics for the Detection of Microstructural Anisotropy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Multi-parametric quantitative evaluation of murine cervical remodeling during pregnancy and postpartum.Scientific reports · 2025Article
- Trajectory of Postpartum Cervical Remodeling in Women Delivering Full-Term and Spontaneous Preterm: Sensitivity to Quantitative Ultrasound Biomarkers.Ultrasound in medicine & biology · 2024Article
- Histological and histochemical features of the mature female reproductive tract of local breed dogJournal of advanced veterinary and animal research · 2024Article
- Whole cervix imaging of collagen, muscle, and cellularity in term and preterm pregnancy.Nature communications · 2024Article
- Review
- Bioengineering and the cervix: The past, current, and future for addressing preterm birth.Current research in physiology · 2023Review
- Three-dimensional anisotropic hyperelastic constitutive model describing the mechanical response of human and mouse cervix.Acta biomaterialia · 2022Article
- Heterogeneous microstructural changes of the cervix influence cervical funneling.Acta biomaterialia · 2022Article
- Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT.Biomedical optics express · 2020Article
- Aspiration technique-based device is more reliable in cervical stiffness assessment than digital palpation.BMC pregnancy and childbirth · 2020Article
- Progesterone Receptor Signaling Selectively Modulates Cytokine-Induced Global Gene Expression in Human Cervical Stromal Cells.Frontiers in genetics · 2020Article
- Immunobiology of Cervix Ripening.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The cervix shortens and softens as its collagen microstructure remodels in preparation for birth. Altered cervical tissue collagen microstructure can contribute to a mechanically weak cervix and premature cervical dilation and delivery. To investigate the local microstructural changes associated with anatomic location and pregnancy, we used second-harmonic generation microscopy to quantify the orientation and spatial distribution of collagen throughout cervical tissue from 4 pregnant and 14 non-pregnant women. Across patients, the alignment and concentration of collagen within the cervix was more variable near the internal os and less variable near the external os. Across anatomic locations, the spatial distribution of collagen within a radial zone adjacent to the inner canal of the cervix was more homogeneous than that of a region comprising the middle and outer radial zones. Two regions with different collagen distribution characteristics were found. The anterior and posterior sections in the outer radial zone were characterized by greater spatial heterogeneity of collagen than that of the rest of the sections. Our findings suggest that the microstructural alignment and distribution of collagen varies with anatomic location within the human cervix. These observed differences in collagen microstructural alignment may reflect local anatomic differences in cervical mechanical loading and function. Our study deepens the understanding of specific microstructural cervical changes in pregnancy and informs investigations of potential mechanisms for normal and premature cervical remodeling.
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