ArticleProceedings of the National Academy of Sciences of the United States of America2018
Optimizing the impact of low-efficacy influenza vaccines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Trial
- Modeling Influenza Antiviral Strategies: Reducing Burden and Preventing Resistance.The Journal of infectious diseases · 2025Article
- Article
- Influenza vaccination allocation in tropical settings under constrained resources.medRxiv : the preprint server for health sciences · 2024Article
- Vaccine Mandates and Influenza Vaccination During the Pandemic.Pediatrics · 2023Article
- Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus.NPJ vaccines · 2023Article
- Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact.F1000Research · 2023Article
- A data-driven spatially-specific vaccine allocation framework for COVID-19.Annals of operations research · 2022Article
- Emergency medical resource allocation among hospitals with non-regressive production technology: A DEA-based approach.Computers & industrial engineering · 2022Article
- Impact of vaccine effectiveness and coverage on preventing large mumps outbreaks on college campuses: Implications for vaccination strategy.Epidemics · 2022Article
- Optimal control of the spatial allocation of COVID-19 vaccines: Italy as a case study.PLoS computational biology · 2022Article
- Efficacy information influences intention to take COVID-19 vaccine.British journal of health psychology · 2022Article
- Article
- Social media effectiveness as a humanitarian response to mitigate influenza epidemic and COVID-19 pandemic.Annals of operations research · 2022Article
- Projected impact of a plant-derived vaccine on the burden of seasonal influenza in Canada.Human vaccines & immunotherapeutics · 2021Article
- COVID-19 vaccination and unemployment risk: lessons from the Italian crisis.Scientific reports · 2021Article
- Article
- Optimizing Spatial Allocation of COVID-19 Vaccine by Agent-Based Spatiotemporal Simulations.GeoHealth · 2021Article
- Losing ground at the wrong time: trends in self-reported influenza vaccination uptake in Switzerland, Swiss Health Survey 2007-2017.BMJ open · 2021Article
- Strategic spatiotemporal vaccine distribution increases the survival rate in an infectious disease like Covid-19.Scientific reports · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
The efficacy of influenza vaccines varies from one year to the next, with efficacy during the 2017-2018 season anticipated to be lower than usual. However, the impact of low-efficacy vaccines at the population level and their optimal age-specific distribution have yet to be ascertained. Applying an optimization algorithm to a mathematical model of influenza transmission and vaccination in the United States, we determined the optimal age-specific uptake of low-efficacy vaccine that would minimize incidence, hospitalization, mortality, and disability-adjusted life-years (DALYs), respectively. We found that even relatively low-efficacy influenza vaccines can be highly impactful, particularly when vaccine uptake is optimally distributed across age groups. As vaccine efficacy declines, the optimal distribution of vaccine uptake shifts toward the elderly to minimize mortality and DALYs. Health practitioner encouragement and concerted recruitment efforts are required to achieve optimal coverage among target age groups, thereby minimizing influenza morbidity and mortality for the population overall.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.