ArticleProceedings of the National Academy of Sciences of the United States of America2018
Tunneling explains efficient electron transport via protein junctions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Pooled it
- Antibody-detecting resistive biosensor for protein biomarkers.Microsystems & nanoengineering · 2026Article
- Solvent Environment Influences Molecular Conformation and Electron Transport in Peptides.The journal of physical chemistry letters · 2026Article
- Phosphorylation-Dependent Charge Transport in Biomolecular Junctions of Major Histocompatibility Complex Phosphopeptides.The journal of physical chemistry. B · 2026Article
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Article
- Protein chains in tight-binding framework.Journal of molecular modeling · 2025Article
- Quantum transport in protein chains.Scientific reports · 2025Article
- Azurin: A Model to Study a Metal Coordination Sphere or Electron Transfer in Metalloproteins.International journal of molecular sciences · 2025Review
- Conductance Channels in a Single-Entity Enzyme.The journal of physical chemistry letters · 2024Article
- Electron transport through two interacting channels in Azurin-based solid-state junctions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Secondary structure determines electron transport in peptides.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Coherent spin transport in a copper protein.Journal of molecular modeling · 2024Article
- Near-Temperature-Independent Electron Transport Well beyond Expected Quantum Tunneling Range via Bacteriorhodopsin Multilayers.Journal of the American Chemical Society · 2023Article
- Long-Range Conductivity in Proteins Mediated by Aromatic Residues.ACS physical chemistry Au · 2023Article
- Fabrication of electron tunneling probes for measuring single-protein conductance.Nature protocols · 2023Review
- Biotin Binding Hardly Affects Electron Transport Efficiency across Streptavidin Solid-State Junctions.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Charge Transport across Proteins inside Proteins: Tunneling across Encapsulin Protein Cages and the Effect of Cargo Proteins.Biomolecules · 2023Article
- Systematic Full-Cycle Engineering Microbial Biofilms to Boost Electricity Production inResearch (Washington, D.C.) · 2023Article
- Measuring conductance switching in single proteins using quantum tunneling.Science advances · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metalloproteins, proteins containing a transition metal ion cofactor, are electron transfer agents that perform key functions in cells. Inspired by this fact, electron transport across these proteins has been widely studied in solid-state settings, triggering the interest in examining potential use of proteins as building blocks in bioelectronic devices. Here, we report results of low-temperature (10 K) electron transport measurements via monolayer junctions based on the blue copper protein azurin (Az), which strongly suggest quantum tunneling of electrons as the dominant charge transport mechanism. Specifically, we show that, weakening the protein-electrode coupling by introducing a spacer, one can switch the electron transport from off-resonant to resonant tunneling. This is a consequence of reducing the electrode's perturbation of the Cu(II)-localized electronic state, a pattern that has not been observed before in protein-based junctions. Moreover, we identify vibronic features of the Cu(II) coordination sphere in transport characteristics that show directly the active role of the metal ion in resonance tunneling. Our results illustrate how quantum mechanical effects may dominate electron transport via protein-based junctions.
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