Evidence map›Paper›PMID 29712790›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects.

Eduardo B Sequerra, Raman Goyal, Patricio A Castro, Jacqueline B Levin, Laura N Borodinsky

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Vesicular Glutamate Release Is Necessary for Neural Tube Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. HCN2 Channel-Induced Rescue of Brain TeratogenesisFrontiers in cellular neuroscience · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eduardo B SequerraDepartment of Physiology and Membrane Biology and Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children, University of California Davis School of Medicine, Sacramento, California 95817.ORCID 0000-0002-8557-0947
Raman GoyalDepartment of Physiology and Membrane Biology and Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children, University of California Davis School of Medicine, Sacramento, California 95817.
Patricio A CastroDepartment of Physiology and Membrane Biology and Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children, University of California Davis School of Medicine, Sacramento, California 95817.ORCID 0000-0002-8131-3265
Jacqueline B LevinDepartment of Physiology and Membrane Biology and Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children, University of California Davis School of Medicine, Sacramento, California 95817.
Laura N BorodinskyDepartment of Physiology and Membrane Biology and Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children, University of California Davis School of Medicine, Sacramento, California 95817 lnborodinsky@ucdavis.edu.ORCID 0000-0003-2937-7023
Shriners Hospitals for Children - Erie · US

Funding

Spinal Cord Development: Interplay Between Electrical Activity and Sonic HedgehogR01NS073055 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BORODINSKY, LAURA NOEMI · 2011 to 2015
$1.6M
NINDS NIH HHS R01 NS073055
6 · The paper itself

Abstract

Failure of neural tube closure leads to neural tube defects (NTDs), which can have serious neurological consequences or be lethal. Use of antiepileptic drugs (AEDs) during pregnancy increases the incidence of NTDs in offspring by unknown mechanisms. Here we show that during

Indexed as

AnimalsAnticonvulsantsCalcium SignalingCell MovementCell ProliferationFemaleGlutamatesMAP Kinase Signaling SystemNeural PlateNeural TubeNeural Tube DefectsReceptors, N-Methyl-D-AspartateSignal TransductionValproic AcidXenopus laevisAnticonvulsantsGlutamatesReceptors, N-Methyl-D-AspartateValproic Acidbirth defectscalcium dynamicsepilepsyglutamate signalingneural platevalproic acid

Identifiers

PMID29712790
PMCPMC5956989
OpenAlexW2802698671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.