Evidence map›Paper›PMID 29712736›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Association of Pulse Wave Velocity With Chronic Kidney Disease Progression and Mortality: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).

Raymond R Townsend, Amanda Hyre Anderson, Julio A Chirinos, Harold I Feldman, Juan E Grunwald, Lisa Nessel, Jason Roy, Matthew R Weir, Jackson T Wright, Nisha Bansal and 2 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07768865 (Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease), which is not on this map. Cited by 105 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 3 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07768865 recruitingnot on this mapstarted 2026, after this paper: background citation

Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease

TypeobservationalSponsorKing's College LondonRan2026 to 2028Enrolled200ConditionsChronic Kidney Disease, Hypertension
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.

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  5. Carotid energy pulsatility index provides complementary hemodynamic information to renal function in a community-based cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Raymond R TownsendFrom the Department of Medicine, Perelman School of Medicine (R.R.T., J.A.C., H.I.F.) townsend@upenn.edu.
Amanda Hyre Andersonand Center for Clinical Epidemiology and Biostatistics (A.H.A., H.I.F., L.N., J.R.).
Julio A ChirinosFrom the Department of Medicine, Perelman School of Medicine (R.R.T., J.A.C., H.I.F.).
Harold I FeldmanFrom the Department of Medicine, Perelman School of Medicine (R.R.T., J.A.C., H.I.F.).
Juan E GrunwaldUniversity of Pennsylvania, Philadelphia; Department of Ophthalmology, University of Pennsylvania Medical School, Philadelphia (J.E.G.).
Lisa Nesseland Center for Clinical Epidemiology and Biostatistics (A.H.A., H.I.F., L.N., J.R.).
Jason Royand Center for Clinical Epidemiology and Biostatistics (A.H.A., H.I.F., L.N., J.R.).
Matthew R WeirDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore (M.R.W.).
Jackson T WrightWilliam T. Dahms MD Clinical Research Unit, Clinical Hypertension Program, University Hospitals Case Medical Center (J.T.W.).
Nisha BansalCase Western Reserve University, OH; Division of Nephrology, Kidney Research Institute, University of Washington, Seattle (N.B.).
Chi-Yuan HsuDivision of Nephrology, University of California, San Francisco (C.-y.H.).
CRIC Study Investigators
Center for Clinical Research (United States) · USUniversity of Maryland, Baltimore · USKaiser Permanente · USUniversity Hospitals Case Medical Center · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
Scientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) StudyU24DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Amanda Hyre Anderson, Laura M Dember · 2018 to 2026
$21.5M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI POSTOLACHE, TEODOR T · 2002 to 2009
$20.2M
Study of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5M
CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR002003NCATS NIH HHS UL1 TR003098NCRR NIH HHS C06 RR028609NCRR NIH HHS G20 RR030969NCRR NIH HHS KL2 RR024130NCRR NIH HHS KL2 RR024987NCRR NIH HHS KL2 RR029878NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR024986NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR029879NIDDK NIH HHS K01 DK092353NIDDK NIH HHS R01 DK067390NIDDK NIH HHS R01 DK072231NIDDK NIH HHS R01 DK139225NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01 DK061028NIDDK NIH HHS U24 DK060990NIGMS NIH HHS P30 GM103337
6 · The paper itself

Abstract

Patients with chronic kidney diseases (CKDs) are at risk for further loss of kidney function and death, which occur despite reasonable blood pressure treatment. To determine whether arterial stiffness influences CKD progression and death, independent of blood pressure, we conducted a prospective cohort study of CKD patients enrolled in the CRIC study (Chronic Renal Insufficiency Cohort). Using carotid-femoral pulse wave velocity (PWV), we examined the relationship between PWV and end-stage kidney disease (ESRD), ESRD or halving of estimated glomerular filtration rate, or death from any cause. The 2795 participants we enrolled had a mean age of 60 years, 56.4% were men, 47.3% had diabetes mellitus, and the average estimated glomerular filtration rate at entry was 44.4 mL/min per 1.73 m

Indexed as

AdultAgedBlood Flow VelocityBlood PressureCarotid ArteriesCause of DeathDisease ProgressionFemaleGlomerular Filtration RateHumansHypertensionMaleMiddle AgedPulse Wave AnalysisRenal Insufficiency, ChronicRetrospective Studiesfollow-up studieshumanskidney failure, chronicrenal insufficiency, chronicvascular stiffness

Identifiers

PMID29712736
PMCPMC6342478
OpenAlexW2800321711

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.