Evidence map›Paper›PMID 29712685›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Novel Effector Phenotype of Tim-3

Zhuqing Liu, Elizabeth L McMichael, Gulidanna Shayan, Jing Li, Kevin Chen, Raghvendra Srivastava, Lawrence P Kane, Binfeng Lu, Robert L Ferris

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Trends in immunotherapy for oral squamous cell carcinoma.Cellular oncology (Dordrecht, Netherlands) · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhuqing Liu *Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China.
Elizabeth L McMichael *Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Gulidanna ShayanSchool of Medicine, Tsinghua University, Beijing, China.
Jing LiSchool of Medicine, Tsinghua University, Beijing, China.
Kevin ChenDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Raghvendra SrivastavaDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Lawrence P KaneDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Binfeng LuDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Robert L FerrisDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania. ferrisrl@upmc.edu.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
WILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6M
Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytesR01CA206517 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert L. Ferris, Lawrence P. Kane · 2016 to 2026
$4.6M
Postdoctoral Training in Head and Neck OncologyT32CA060397 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZEVALLOS, JOSE P. · 1994 to 2024
$2.7M
Immune activation by cetuximab in head and neck cancer patientsR01DE019727 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FERRIS, ROBERT L. · 2010 to 2014
$2.0M
NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA206517NCI NIH HHS T32 CA060397NCI NIH HHS T32 CA082084NIDCR NIH HHS R01 DE019727
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunotherapyAnimalsAntigens, CDApyraseCell ProliferationCTLA-4 AntigenFlow CytometryGene Expression Regulation, NeoplasticHepatitis A Virus Cellular Receptor 2HumansInterferon-gammaLymphocyte ActivationLymphocytes, Tumor-InfiltratingMiceProgrammed Cell Death 1 ReceptorSquamous Cell Carcinoma of Head and NeckAntigens, CDApyraseCD39 antigenCTLA-4 AntigenHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2IFNG protein, mouseInterferon-gammaPdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID29712685
PMCPMC6139056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.