ArticleDiabetes2018
Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 5 pooled it
15.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
206 citing papers in PubMed, 5 syntheses or guidelines pooled it, 377 citations in OpenAlex.
- Clinical trials targeting the gut-microbiome to effect ocular health: a systematic review.Eye (London, England) · 2023Pooled it
- Diet and ideal food pyramid to prevent or support the treatment of diabetic retinopathy, age-related macular degeneration, and cataracts.Frontiers in medicine · 2023Pooled it
- Intermittent Fasting versus Continuous Calorie Restriction: Which Is Better for Weight Loss?Nutrients · 2022Pooled it
- Religious fasting and its impacts on individual, public, and planetary health: Fasting as a "religious health asset" for a healthier, more equitable, and sustainable society.Frontiers in nutrition · 2022Pooled it
- Ocular Microbiota and Intraocular Inflammation.Frontiers in immunology · 2020Pooled it
- Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial.Genome medicine · 2022Trial
- Gut microbiota-bile acid axis in cardiovascular disease: a spatiotemporal framework for predictive, preventive and personalised medicine.The EPMA journal · 2026Review
- Intermittent fasting in diabetic retinopathy: microbiome modulation, mechanisms, and clinical insights.Cardiovascular endocrinology & metabolism · 2026Review
- Intermittent Fasting and the Gut Microbiota: Mechanisms Linking Microbial Remodeling to Metabolic and Immune Regulation.Nutrients · 2026Review
- An Update and Overview of the Ocular and Extraocular Microbiome and Its Impact on Ophthalmic Care.Advances in therapy · 2026Review
- GutMGene-Guided Peripheral Blood Transcriptomics Identifies an FLNA-Associated Host-Gene Signal in Diabetic Retinopathy.International journal of molecular sciences · 2026Article
- Pomegranate peel extract alleviates diabetic retinopathy by suppressing the PI3K/AKT/HIF-1α/VEGF pathway and gut microbiota modulation.Journal of advanced research · 2026Article
- Intermittent Fasting and Risk of Diabetic Retinopathy: Retrospective Data from the National Health and Nutrition Examination Survey.Nutrients · 2026Article
- The Gut-Eye Axis and Microbiome in Ophthalmic Diseases: A Narrative Review.Journal of clinical medicine · 2026Review
- Experimental Diabetic Retinopathy in Wistar Rats Induced by Streptozotocin: A Window into Retinal Disease Progression.International journal of molecular sciences · 2026Article
- Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye.Cellular & molecular biology letters · 2026Article
- Deciphering the Microbiome-Gut-Eye Axis: A Mendelian Randomization Analysis of the Causal Influence of Gut Microbiota on Myopia.Combinatorial chemistry & high throughput screening · 2026Article
- Restoring circadian disrupted gut microbial metabolite rhythms with phytochemicals: a new avenue against metabolic disease.Frontiers in microbiology · 2026Review
- Intermittent fasting ameliorates diabetes-induced meibomian gland dysfunction in mice.International journal of ophthalmology · 2026Article
- The gut-eye axis in blinding eye diseases: microbiota-driven immune dysregulation and immunomodulatory therapies.International ophthalmology · 2025Review
146 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 13 institutions in 2 countries.
Eleni BeliDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
Yuanqing YanDepartment of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, TX.
Leni MoldovanDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN.
Cristiano P VieiraDepartment of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, AL.
Ruli GaoDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Yaqian DuanDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
Ram PrasadDepartment of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, AL.
Ashay BhatwadekarDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0003-0190-0505
Fletcher A WhiteDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN.
Steven D TownsendDepartment of Chemistry, Vanderbilt University, Nashville, TN.
Luisa ChanSecond Genome, Inc., San Francisco, CA.
Caitlin N RyanSecond Genome, Inc., San Francisco, CA.
Daniel MortonSecond Genome, Inc., San Francisco, CA.
Emil G MoldovanNortheastern University, Boston, MA.
Fang-I ChuDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA.
Gavin Y OuditDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Hartmut DerendorfDepartment of Pharmaceutics, University of Florida, Gainesville, FL.
Luciano AdoriniIntercept Pharmaceuticals, New York, NY.
Xiaoxin X WangDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC.
Carmella Evans-MolinaDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-7764-8663
Raghavendra G MirmiraDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0002-5013-6075
Michael E BoultonDepartment of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, AL.
Mervin C YoderDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
Qiuhong LiDepartment of Ophthalmology, University of Florida, Gainesville, FL.
Moshe LeviDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC.
Julia V BusikDepartment of Physiology, Michigan State University, East Lansing, MI.ORCID 0000-0003-3453-7124
Maria B GrantDepartment of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, AL mariagrant@uabmc.edu.ORCID 0000-0002-3602-8844
Indiana University School of MedicineUniversity of Alabama · USSecond Genome (United States) · USGeorgetown University · USUniversity of Florida · USIntercept Pharmaceuticals (United States) · USMichigan State University · USNortheastern University · USThe University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alberta · CAUniversity of California, Los Angeles · USVanderbilt University · US
Funding
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLIAM H HERMAN · 2013 to 2026
$24.3MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MNITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6MTranscriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5MOral immune modulatory therapy using antigens bioencapsulated in plant cellsR01HL107904 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DANIELL, HENRY · 2011 to 2023
$7.5MTargeting the IGF-1 System in Retinal AngiogenesisR01EY007739 · NEI · UNIVERSITY OF FLORIDA · PI ABCOUWER, STEVEN F, GRANT, MARIA BARTOLOMEO · 1995 to 2015
$5.4MLXR as a Novel Therapeutic Target in Diabetic RetinopathyR01EY025383 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUSIK, JULIA V, GRANT, MARIA BARTOLOMEO · 2015 to 2024
$4.2MMechanisms of Beta Cell Function in Health and DiseaseR01DK093954 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2011 to 2019
$3.5MOPTIMIZING SYSTEMIC STEM/PROGENITOR CELL THERAPY FOR AMDR01EY023629 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2013 to 2017
$2.7MBiomarkers Of Beta Cell Stress In Type 1 Diabetes (BetaMarker)UC4DK104166 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EIZIRIK, DECIO LAKS, EVANS-MOLINA, CARMELLA · 2014 to 2014
$2.4MRetinal dysfunction in Alzheimer's disease mouse modelsR01EY027779 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BHATWADEKAR, ASHAY D · 2017 to 2021
$2.4MBLRD VA I01 BX001733NEI NIH HHS R01 EY007739NEI NIH HHS R01 EY012601NEI NIH HHS R01 EY021752NEI NIH HHS R01 EY023629NEI NIH HHS R01 EY024564NEI NIH HHS R01 EY025383NEI NIH HHS R01 EY027779NEI NIH HHS R01 EY028037NHLBI NIH HHS R01 HL110170NIA NIH HHS R01 AG049493NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK093954NIDDK NIH HHS UC4 DK104166
Abstract
Intermittent fasting (IF) protects against the development of metabolic diseases and cancer, but whether it can prevent diabetic microvascular complications is not known. In
Indexed as
FastingGastrointestinal MicrobiomeAnimalsBacillotaBacteroidetesBile Acids and SaltsColonDiabetes Mellitus, Type 2Diabetic RetinopathyDysbiosisFecesGanglia, SensoryGoblet CellsIntestinal MucosaLeukocytesMale6-ethyl-24-norcholane-3,7,23-triol-23 sulfateBile Acids and SaltsGpbar1 protein, mouseReceptors, G-Protein-Coupled
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.