Evidence map›Paper›PMID 29710854›Full record

ArticleMarine drugs2018

Frondanol, a Nutraceutical Extract from

Sandeep B Subramanya, Sanjana Chandran, Saeeda Almarzooqi, Vishnu Raj, Aisha Salem Al Zahmi, Radeya Ahmed Al Katheeri, Samira Ali Al Zadjali, Peter D Collin, Thomas E Adrian

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05194007 (A Pilot Randomized, Double-blind, Placebo-controlled Trial to Investigate the Anti-inflammatory Effects of Frondanol in Adults With Inflammatory Bowel Disease), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05194007 phase2 / phase3completednot on this mapstarted 2022, after this paper: background citation

A Pilot Randomized, Double-blind, Placebo-controlled Trial to Investigate the Anti-inflammatory Effects of Frondanol in Adults With Inflammatory Bowel Disease

TypeinterventionalSponsorMohammed Bin Rashid University of Medicine and Health SciencesRan2022 to 2024Enrolled13ConditionsUlcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate, Crohn ColitisArmsFrondanol, Placebo
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. The Effect ofFoods (Basel, Switzerland) · 2025
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  10. Review
  11. Effect ofFrontiers in microbiology · 2022
    Article
  12. PPAR research · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Northern Sea Cucumber (Marine drugs · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sandeep B SubramanyaDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. sandeep.bs@uaeu.ac.ae.
Sanjana ChandranDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. sanjanachandran25@gmail.com.
Saeeda AlmarzooqiDepartment of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. saeeda.almarzooqi@uaeu.ac.ae.
Vishnu RajDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. rajvishnu@uaeu.ac.ae.
Aisha Salem Al ZahmiDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. 201400107@uaeu.ac.ae.
Radeya Ahmed Al KatheeriDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. 201304934@uaeu.ac.ae.
Samira Ali Al ZadjaliDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. 201304302@uaeu.ac.ae.
Peter D CollinCoastside Bio Resources, Deer Isle, ME 04627, USA. pcollin48@gmail.com.
Thomas E AdrianDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box⁻17666, Al Ain, UAE. tadrian@uaeu.ac.ae.
United Arab Emirates University · AECoastside Bio Resources (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frondanol is a nutraceutical lipid extract of the intestine of the edible Atlantic sea cucumber,

Indexed as

AnimalsAntigens, DifferentiationChemokine CXCL2ColitisComplex MixturesCucumariaCytokinesDextran SulfateDietary SupplementsGene Expression RegulationMaleMiceMice, Inbred C57BLPeroxidaseRNA, MessengerAntigens, DifferentiationChemokine CXCL2Complex MixturesCxcl2 protein, mouseCytokinesDextran SulfateFrondanol-A5Pmonocyte-macrophage differentiation antigenPeroxidaseRNA, Messengercolon inflammationCucumaria frondosaDSS colitisFrondanol

Identifiers

PMID29710854
PMCPMC5983279
OpenAlexW2801954618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.