Evidence map›Paper›PMID 29710770›Full record

ReviewInternational journal of environmental research and public health2018

Exercise Early and Often: Effects of Physical Activity and Exercise on Women's Bone Health.

Karen L Troy, Megan E Mancuso, Tiffiny A Butler, Joshua E Johnson

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04862910 (Effects of Kinect-based Virtual Reality Training on Bone Mineral Density, Fracture Risk, Physical Performance and Quality of Life in Postmenopausal Women With Osteopenia), which is not on this map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04862910 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Kinect-based Virtual Reality Training on Bone Mineral Density, Fracture Risk, Physical Performance and Quality of Life in Postmenopausal Women With Osteopenia

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2023Enrolled52ConditionsPostmenopausal OsteopeniaArmsKinect Based Virtual Reality Training, Control Group
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Biomechanics of a Drop Landing: Osteogenic Stimulus Measures May Vary.Journal of musculoskeletal & neuronal interactions · 2025
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen L TroyDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01545 USA. ktroy@wpi.edu.
Megan E MancusoDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01545 USA. memancuso@wpi.edu.
Tiffiny A ButlerDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01545 USA. tbutler@wpi.edu.
Joshua E JohnsonDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01545 USA. jejohnson@wpi.edu.

Funding

A prospective study of human bone adaptation using a novel in-vivo loading modelR01AR063691 · NIAMS · WORCESTER POLYTECHNIC INSTITUTE · PI TROY, KAREN L · 2012 to 2015
$1.6M
Smoking effects on bone microstructure, mechanical strength, and fracture healingF32AR068839 · NIAMS · WORCESTER POLYTECHNIC INSTITUTE · PI JOHNSON, JOSHUA · 2016 to 2017
$119k
NIAMS NIH HHS F32 AR068839NIAMS NIH HHS R01 AR063691
6 · The paper itself

Abstract

In 2011 over 1.7 million people were hospitalized because of a fragility fracture, and direct costs associated with osteoporosis treatment exceeded 70 billion dollars in the United States. Failure to reach and maintain optimal peak bone mass during adulthood is a critical factor in determining fragility fracture risk later in life. Physical activity is a widely accessible, low cost, and highly modifiable contributor to bone health. Exercise is especially effective during adolescence, a time period when nearly 50% of peak adult bone mass is gained. Here, we review the evidence linking exercise and physical activity to bone health in women. Bone structure and quality will be discussed, especially in the context of clinical diagnosis of osteoporosis. We review the mechanisms governing bone metabolism in the context of physical activity and exercise. Questions such as, when during life is exercise most effective, and what specific types of exercises improve bone health, are addressed. Finally, we discuss some emerging areas of research on this topic, and summarize areas of need and opportunity.

Indexed as

Women's HealthAdolescentAdultBone DensityBone RemodelingExerciseFemaleHealth BehaviorHealthy LifestyleHumansOsteoporosis, PostmenopausalProtective FactorsRisk Factorsareal bone mineral densitybone adaptationbone mineral densityhigh resolution peripheral quantitative computed tomographymechanical loadingquantitative computed tomographystructurevolumetric bone mineral density

Identifiers

PMID29710770
PMCPMC5981917

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.