Evidence map›Paper›PMID 29710718›Full record

ArticleJournal of Alzheimer's disease : JAD2018

The Progressive Acalculia Presentation of Parietal Variant Alzheimer's Disease.

Mario F Mendez, Negar Moheb, Randy E Desarzant, Edmond H Teng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Numerical activities of daily living: a short version.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  4. Article
  5. Article
  6. Early-onset Alzheimer Disease and Its Variants.Continuum (Minneapolis, Minn.) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mario F MendezDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Negar MohebDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Randy E DesarzantDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Edmond H TengDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

Early-Onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksRF1AG050967 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2016 to 2016
$1.9M
NIA NIH HHS RF1 AG050967
6 · The paper itself

Abstract

backgroundMany patients with early-onset Alzheimer's disease (EOAD; age of onset <65 years) have non-amnestic presentations involving language (logopenic primary progressive aphasia, lvPPA), visuospatial abilities (posterior cortical atrophy, PCA), and even asymmetric symptoms consistent with corticobasal syndrome (CBS). An inferior parietal lobule variant of EOAD commonly presents with progressive difficulty with calculations.

methodsWe reviewed 276 EOAD patients for presentations with predominant acalculia. These patients were diagnosed with clinically probable Alzheimer's disease (AD) verified by positron emission tomography (PET) or cerebrospinal fluid amyloid-β or tau biomarkers.

resultsWe identified 18 (9M/9F) (6.5%) EOAD patients with progressive acalculia that did not meet most criteria for lvPPA, visual PCA, or CBS. Their ages of onset and presentation were 56.6 (5.0) and 59.4 (6.5), respectively. Their acalculia was consistent with a primary acalculia ("anarithmetia") not explained by language or visuospatial impairments. Many also had anomia (14/18), ideomotor apraxia (13/18), and the complete Gerstmann's syndrome (7/18). Visual analysis of their diverse magnetic resonance imaging disclosed biparietal atrophy, disproportionately worse on the left.

conclusionsPrimary acalculia may be the most common manifestation of an inferior parietal presentation of EOAD affecting the left intraparietal sulcus. This parietal variant also commonly involves progressive anomia, ideomotor apraxia, and other elements of Gerstmann's syndrome. The early recognition of patients with this variant, which is distinguishable from lvPPA, visual PCA, or CBS, would be facilitated by its recognition as a unique subtype of EOAD.

Indexed as

Disease ProgressionAgedAlzheimer DiseaseBrainDyscalculiaFemaleHumansMaleMiddle AgedNeuroimagingAcalculiaAlzheimer’s diseaseapraxiaGerstmann’s syndromeparietal variant

Identifiers

PMID29710718
PMCPMC6535210
OpenAlexW2802109092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.