ArticleAnatomical record (Hoboken, N.J. : 2007)2018
Adipose Derived Stem Cells Reduce Fibrosis and Promote Nerve Regeneration in Rats.
Article in Anatomical record (Hoboken, N.J. : 2007), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04653129 (Use of Autologous Fat to Improve Functional Outcomes After Upper Limb Nerve Injuries), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Autologous Fat to Improve Functional Outcomes After Upper Limb Nerve Injuries
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Millesi's Classification of Nerve Fibrosis Remains Underutilized in Modern Peripheral Nerve Research.Muscle & nerve · 2026Review
- Optimization of fat grafting to attenuate radiation damage: a narrative review.Gland surgery · 2026Review
- Human platelet lysate stimulates neurotrophic properties of human adipose-derived stem cells better than Schwann cell-like cells.Stem cell research & therapy · 2023Article
- Translational bioengineering strategies for peripheral nerve regeneration: opportunities, challenges, and novel concepts.Neural regeneration research · 2023Review
- Improving Schwann Cell Differentiation from Human Adipose Stem Cells with Metabolic Glycoengineering.Cells · 2023Article
- Sciatic Nerve Plastic Surgery using Autologous Adipose Tissue.Sovremennye tekhnologii v meditsine · 2023Article
- Thermosensitive hydrogel carrying extracellular vesicles from adipose-derived stem cells promotes peripheral nerve regeneration after microsurgical repair.APL bioengineering · 2022Article
- Role of adipose tissue grafting and adipose-derived stem cells in peripheral nerve surgery.Neural regeneration research · 2022Review
- Synergy of human platelet lysate and laminin to enhance the neurotrophic effect of human adipose-derived stem cells.Neural regeneration research · 2022Article
- Electromagnetic Fields Generated by the IteraCoil Device Differentiate Mesenchymal Stem Progenitor Cells Into the Osteogenic Lineage.Bioelectromagnetics · 2022Article
- Augmenting Peripheral Nerve Regeneration with Adipose-Derived Stem Cells.Stem cell reviews and reports · 2022Review
- Secondary release of the peripheral nerve with autologous fat derivates benefits for functional and sensory recovery.Neural regeneration research · 2021Article
- Defining the regenerative effects of native spider silk fibers on primary Schwann cells, sensory neurons, and nerve-associated fibroblasts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Reconstruction of the Rat Sciatic Nerve by Using Biodegradable and Non-Biodegradable Conduits.Sovremennye tekhnologii v meditsine · 2021Article
- Effect of Systemic Adipose-derived Stem Cell Therapy on Functional Nerve Regeneration in a Rodent Model.Plastic and reconstructive surgery. Global open · 2020Article
- Recent advances toward understanding the role of transplanted stem cells in tissue-engineered regeneration of musculoskeletal tissues.F1000Research · 2020Review
- The protective role of Schwann cells in bladder smooth muscle cell fibrosis.International journal of clinical and experimental pathology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Peripheral nerve regeneration is critical and challenging in the adult humans. High level of collagen infiltration (i.e., scar tissue), in the niche of injury, impedes axonal regeneration and path finding. Unfortunately, studies focusing on the modulation of scar tissue in the nerves are scarce. To address part of this problem, we have evaluated the differentiated adipose derived stem cells (dASCs) for their antifibrotic and regenerative effects in a 10 mm nerve gap model in rats. Three different animal groups (N = 5) were treated with fibrin nerve conduits (empty), or seeded with dASCs (F + dASCs) and autograft, respectively. Histological analysis of regenerated nerves, at 12 weeks postoperatively, reveled the high levels of collagen infiltration (i.e., 21.5% ± 6.1% and 24.1% ± 2.9%) in the middle and distal segment of empty conduit groups in comparison with stem cells treated (16.6% ± 2.1% and 12.1% ± 2.9%) and autograft (15.0% ± 1.7% and 12.8% ± 1.0%) animals. Thus, the dASCs treatment resulted in significant reduction of fibrotic tissue formation. Consequently, enhanced axonal regeneration and remyelination was found in the animals treated with dASCs. Interestingly, these effects of dASCs appeared to be equivalent to that of autograft treatment. Thus, the dASCs hold great potential for preventing the scar tissue formation and for promoting nerve regeneration in the adult organisms. Future experiments will focus on the validation of these findings in a critical nerve injury model. Anat Rec, 301:1714-1721, 2018. © 2018 Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.