Evidence map›Paper›PMID 29710393›Full record

ArticleCancer2018

Increasing prevalence of human papillomavirus-positive oropharyngeal cancers among older adults.

Melina J Windon, Gypsyamber D'Souza, Eleni M Rettig, William H Westra, Annemieke van Zante, Steven J Wang, William R Ryan, Wojciech K Mydlarz, Patrick K Ha, Brett A Miles and 4 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05291663 (Retrospective Study of Effect of Accelerated Radiation Therapy , Six Fractions Per Week , for Squamous Cell Carcinoma of Head and Neck.), which is not on this map. Cited by 89 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05291663 unknown statusnot on this mapstarted 2022, after this paper: background citation

Retrospective Study of Effect of Accelerated Radiation Therapy , Six Fractions Per Week , for Squamous Cell Carcinoma of Head and Neck.

TypeobservationalSponsorAssiut UniversityRan2022 to 2023Enrolled100ConditionsHead and Neck Squamous Cell Carcinoma
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 1 synthesis or guideline pooled it, 161 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Explore the role of ctHPVDNA kinetics during diagnosis and follow-up of HPV OPSCC.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Direct Comparison of Alternative Blood-Based Approaches for Early Detection and Diagnosis of HPV-Associated Head and Neck Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Translational cancer research · 2024
    Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Melina J WindonDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-0904-2931
Gypsyamber D'SouzaDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
Eleni M RettigDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
William H WestraDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Annemieke van ZanteHead and Neck Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, California.
Steven J WangHead and Neck Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, California.
William R RyanHead and Neck Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, California.
Wojciech K MydlarzDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
Patrick K HaHead and Neck Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, California.
Brett A MilesDepartment of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
Wayne KochDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-9499-1516
Christine GourinDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
David W EiseleDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
Carole FakhryDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-5251-6178
Johns Hopkins University · USUniversity of California, San Francisco · USBloomberg (United States) · USIcahn School of Medicine at Mount Sinai · US

Funding

TUMOR SUPPRESOR GENE PROMOTER HYPERMETHYLATION FOR DETECTION OF HEAD AND NECKP50DE019032 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI SIDRANSKY, DAVID · 2007 to 2016
$27.1M
Impacting the oral HPV continuum: prevention, screening, and early detectionR35DE026631 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER · 2016 to 2023
$8.4M
RESEARCH TRAINING IN OTOLARYNGOLOGYT32DC000027 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CAREY, JOHN PATRICK · 1989 to 2023
$5.5M
NIDCD NIH HHS T32 DC000027NIDCR NIH HHS P50 DE019032NIDCR NIH HHS R35 DE026631
6 · The paper itself

Abstract

backgroundThe incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults. It is unknown whether these trends can be explained by human papillomavirus (HPV) and whether HPV-related tumors remain associated with an improved prognosis among older patients.

methodsIn a retrospective study of OPSCCs diagnosed from 1995 to 2013 at 2 National Comprehensive Cancer Network-designated cancer centers, p16 immunohistochemistry and in situ hybridization (ISH) for HPV-16, high-risk DNA, and/or E6/E7 RNA were performed. The median age at diagnosis was compared by p16 and ISH tumor status. Trends in age were analyzed with nonparametric trends. Survival was analyzed with the Kaplan-Meier method and Cox proportional hazards models.

resultsAmong 239 patients, 144 (60%) were p16-positive. During 1998-2013, the median age increased among p16-positive patients (P

conclusionsThe median age at diagnosis for HPV-related OPSCC is increasing as the proportion of OPSCCs caused by HPV rises among older adults. The favorable survival conferred by an HPV-positive tumor status persists in older adults. Cancer 2018;124:2993-9. © 2018 American Cancer Society.

Indexed as

AdultAgedAge FactorsCaliforniaDNA, ViralFemaleHuman papillomavirus 16HumansKaplan-Meier EstimateMaleMarylandMiddle AgedOropharyngeal NeoplasmsPapillomavirus InfectionsPrevalencePrognosisDNA, Viralelderlyhead and neck squamous cell carcinoma (HNSCC)human papillomavirus (HPV)in situ hybridization (ISH)oropharyngeal squamous cell carcinoma (OPSCC)p16

Identifiers

PMID29710393
PMCPMC6033632
OpenAlexW2802681048

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.