ArticleThe Journal of reproduction and development2018
Heat stress affects prostaglandin synthesis in bovine endometrial cells.
Article in The Journal of reproduction and development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Heat shock suppresses the innate immune response of bovine endometrial epithelial cells.Reproduction & fertility · 2026Article
- Heat Stress from Calving to Mating: Mechanisms and Impact on Cattle Fertility.Animals : an open access journal from MDPI · 2025Review
- Forecasting reproductive performance in Holstein heifers and cows in a hot environment: a time-series analysis.Tropical animal health and production · 2025Article
- Specific immune landscape of heatstroke distinguished from sepsis and aseptic inflammation.International journal of medical sciences · 2025Article
- Impact of Heat Stress on Oocyte Developmental Competence and Pre-Implantation Embryo Viability in Cattle.Animals : an open access journal from MDPI · 2024Review
- Disparities in the association between ambient temperature and preterm birth according to individual and regional characteristics: a nationwide time-stratified case-crossover study.Environmental health : a global access science source · 2024Article
- N-3 Polyunsaturated Fatty Acids as a Nutritional Support of the Reproductive and Immune System of Cattle-A Review.Animals : an open access journal from MDPI · 2023Review
- Exploration of the preterm birth risk-related heat event thresholds for pregnant women: a population-based cohort study in China.The Lancet regional health. Western Pacific · 2023Article
- In Vitro Effects of Short-Term and Long-Term Heat Exposures on the Immune Response and Prostaglandin Biosynthesis in Bovine Endometrial Cells.Animals : an open access journal from MDPI · 2022Article
- Effects of extreme temperature on the risk of preterm birth in China: A population-based multi-center cohort study.The Lancet regional health. Western Pacific · 2022Article
- Culture of endometrial epithelial cells collected by a cytological brush in vivo.JDS communications · 2022Article
- Impact of heat stress on embryonic development during first 16 days of gestation in dairy cows.Scientific reports · 2021Article
- Impact of summer heat stress on the thermal environment of bovine female genital tract.Tropical animal health and production · 2020Article
- Alteration of chemokine production in bovine endometrial epithelial and stromal cells under heat stress conditions.Physiological reports · 2020Article
- The Molecular Signatures of Acute-immobilization-induced Antinociception and Chronic-immobilization-induced Antinociceptive Tolerance.Experimental neurobiology · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress (HS) negatively affects reproduction in cattle; however, its effect on endocrine function in bovine endometrial cells remains unclear. In this study, we examined the effects of HS on the production of prostaglandin (PG) E2 and PGF2α in the cultured bovine endometrial epithelial and stromal cells separately. To evaluate the effect of HS on endocrine function, the cells were cultured at 38.5°C (control) or 40.5°C (HS). After treatment, PGE2 and PGF2α levels were measured via enzyme immunoassay (EIA) and mRNA expressions of enzymes involved in PG synthesis were examined via quantitative reverse transcription polymerase chain reaction (RT-PCR). HS did not influence the production of PGE2 or PGF2α in the epithelial cells; however, HS significantly enhanced the production of both PGE2 and PGF2α in the stromal cells (P < 0.05). In addition, HS significantly increased phospholipase A2 (PLA2), cyclooxygenase 2 (COX2), prostaglandin F synthase (PGFS), prostaglandin E synthase (PGES), and carbonyl reductase 1 (CBR1) mRNA expression in the stromal cells (P < 0.05). The overall results suggest that HS induces mRNA expression of enzymes involved in PG synthesis, resulting in the upregulation of PGE2 and PGF2α production in the stromal cells, but not in the epithelial cells. The HS-induced increase of PGE2 and PGF2α secretion in bovine endometrial stromal cells may disrupt the normal estrous cycle and cause infertility in cows during summer.
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