ReviewPharmacology, biochemistry, and behavior2018
Emerging role of viral vectors for circuit-specific gene interrogation and manipulation in rodent brain.
Review in Pharmacology, biochemistry, and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Bidirectional regulation of motor circuits using magnetogenetic gene therapy.Science advances · 2024Article
- Gene replacement therapies for inherited disorders of neurotransmission: Current progress in succinic semialdehyde dehydrogenase deficiency.Journal of inherited metabolic disease · 2024Review
- Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy Short: Magnetogenetic Regulation of Motor Circuits.bioRxiv : the preprint server for biology · 2024Article
- The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Lighting Up Neural Circuits by Viral Tracing.Neuroscience bulletin · 2022Review
- Strategies for Targeting Neural Circuits: How to Manipulate Neurons Using Virus Vehicles.Frontiers in neural circuits · 2022Review
- The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner.Neurobiology of learning and memory · 2021Article
- Delineating the organization of projection neuron subsets in primary visual cortex with multiple fluorescent rabies virus tracing.Brain structure & function · 2021Article
- Recent Advances in the Understanding of Specific Efferent Pathways Emerging From the Cerebellum.Frontiers in neuroanatomy · 2021Review
- Androgen-Dependent Excitability of Mouse Ventral Hippocampal Afferents to Nucleus Accumbens Underlies Sex-Specific Susceptibility to Stress.Biological psychiatry · 2020Article
- Investigating Memory Updating in Mice Using the Objects in Updated Locations Task.Current protocols in neuroscience · 2020Article
- A neuroscientist's guide to transgenic mice and other genetic tools.Neuroscience and biobehavioral reviews · 2020Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Over the past half century, novel tools have allowed the characterization of myriad molecular underpinnings of neural phenomena including synaptic function, neurogenesis and neurodegeneration, membrane excitability, and neurogenetics/epigenetics. More recently, transgenic mice have made possible cell type-specific explorations of these phenomena and have provided critical models of many neurological and psychiatric diseases. However, it has become clear that many critical areas of study require tools allowing the study and manipulation of individual neural circuits within the brain, and viral vectors have come to the forefront in driving these circuit-specific studies. Here, we present a surface-level review of the general classes of viral vectors used for study of the brain, along with their suitability for circuit-specific studies. We then cover in detail a new long-lasting, retrograde expressing form of herpes simplex virus termed LT-HSV that has become highly useful in circuit-based studies. We detail some of its current uses and propose a variety of future uses for this critical new tool, including circuit-based transgene overexpression, gene editing, and gene expression profiling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.