ArticlePLoS genetics2018
Role of heterotrimeric Gα proteins in maize development and enhancement of agronomic traits.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 77 citations in OpenAlex.
- Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits.Journal of integrative plant biology · 2026Review
- Genome-wide identification of maize G protein genes and regulatory roles of the ZmGG1 subfamily in saline-alkali stress response.BMC plant biology · 2026Article
- Phosphovariants of the canonical heterotrimeric Gα protein, GPA1, differentially affect G protein activity and Arabidopsis development.bioRxiv : the preprint server for biology · 2026Article
- Multi-omics analysis of the maize ear diameter mutant3 (zmed3) provides insights into female inflorescence development.BMC plant biology · 2025Article
- The G-protein β subunit SlGB1 regulates tyramine-derived phenolamide metabolism for shoot apex growth and development in tomato.The Plant cell · 2025Article
- Maize COMPACT PLANT 3 regulates plant architecture and facilitates high-density planting.The Plant cell · 2025Article
- Article
- A molecular dynamics study of membrane positioning for 7-transmembrane RGS proteins to modulate G-protein-mediated signaling in plants.Computational and structural biotechnology journal · 2025Article
- Influence of expression and purification protocols on Gα biochemical activity: kinetics of plant and mammalian G protein cycles.Frontiers in molecular biosciences · 2025Article
- Trade-Off Regulation in Plant Growth and Stress Responses Through the Role of Heterotrimeric G Protein Signaling.Plants (Basel, Switzerland) · 2024Review
- GPCR-like Protein ZmCOLD1 Regulate Plant Height in an ABA Manner.International journal of molecular sciences · 2024Article
- Heterotrimeric Gα-subunit regulates flower and fruit development in CLAVATA signaling pathway in cucumber.Horticulture research · 2024Article
- Review
- Stem Cells: Engines of Plant Growth and Development.International journal of molecular sciences · 2023Review
- An atypical heterotrimeric Gα and its interactome suggest an extra-large role in overcoming abiotic and biotic stress.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Extra-large G proteins have extra-large effects on agronomic traits and stress tolerance in maize and rice.Trends in plant science · 2023Review
- G-Protein β-Subunit GeneInternational journal of molecular sciences · 2023Article
- Distribution and the evolutionary history of G-protein components in plant and algal lineages.Plant physiology · 2022Article
- Review
- GIF1 controls ear inflorescence architecture and floral development by regulating key genes in hormone biosynthesis and meristem determinacy in maize.BMC plant biology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant shoot systems derive from the shoot apical meristems (SAMs), pools of stems cells that are regulated by a feedback between the WUSCHEL (WUS) homeobox protein and CLAVATA (CLV) peptides and receptors. The maize heterotrimeric G protein α subunit COMPACT PLANT2 (CT2) functions with CLV receptors to regulate meristem development. In addition to the sole canonical Gα CT2, maize also contains three eXtra Large GTP-binding proteins (XLGs), which have a domain with homology to Gα as well as additional domains. By either forcing CT2 to be constitutively active, or by depleting XLGs using CRISPR-Cas9, here we show that both CT2 and XLGs play important roles in maize meristem regulation, and their manipulation improved agronomic traits. For example, we show that expression of a constitutively active CT2 resulted in higher spikelet density and kernel row number, larger ear inflorescence meristems (IMs) and more upright leaves, all beneficial traits selected during maize improvement. Our findings suggest that both the canonical Gα, CT2 and the non-canonical XLGs play important roles in maize meristem regulation and further demonstrate that weak alleles of plant stem cell regulatory genes have the capacity to improve agronomic traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.