ArticlePLoS biology2018
Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- A low-level Cdkn1c/p57EMBO reports · 2026Article
- Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis.Nature communications · 2025Article
- Persistent Transcriptome Alterations in Zebrafish Embryos After Discontinued Opioid Exposure.International journal of molecular sciences · 2025Article
- Early spinal cord development: from neural tube formation to neurogenesis.Nature reviews. Neuroscience · 2025Review
- Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells.Development (Cambridge, England) · 2024Article
- 3D exploration of gene expression in chicken embryos through combined RNA fluorescence in situ hybridization, immunofluorescence, and clearing.BMC biology · 2024Article
- The role of Hedgehog and Notch signaling pathway in cancer.Molecular biomedicine · 2022Review
- Dynamic switching of lateral inhibition spatial patterns.Journal of the Royal Society, Interface · 2022Article
- The Symmetry of Neural Stem Cell and Progenitor Divisions in the Vertebrate Brain.Frontiers in cell and developmental biology · 2022Review
- Biophysics of Notch Signaling.Annual review of biophysics · 2021Review
- Regulation of size and scale in vertebrate spinal cord development.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.Molecular systems biology · 2021Article
- Multifaceted regulation of Notch signaling by glycosylation.Glycobiology · 2021Review
- Notch signaling: Its essential roles in bone and craniofacial development.Genes & diseases · 2021Review
- Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis.Cell stem cell · 2020Article
- Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches.eLife · 2020Article
- Delta-Notch Signaling: The Long and The Short of a Neuron's Influence on Progenitor Fates.Journal of developmental biology · 2020Review
- Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation.Developmental cell · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The vertebrate neuroepithelium is composed of elongated progenitors whose reciprocal attachments ensure the continuity of the ventricular wall. As progenitors commit to differentiation, they translocate their nucleus basally and eventually withdraw their apical endfoot from the ventricular surface. However, the mechanisms allowing this delamination process to take place while preserving the integrity of the neuroepithelial tissue are still unclear. Here, we show that Notch signaling, which is classically associated with an undifferentiated state, remains active in prospective neurons until they delaminate. During this transition period, prospective neurons rapidly reduce their apical surface and only later down-regulate N-Cadherin levels. Upon Notch blockade, nascent neurons disassemble their junctions but fail to reduce their apical surface. This disrupted sequence weakens the junctional network and eventually leads to breaches in the ventricular wall. We also provide evidence that the Notch ligand Delta-like 1 (Dll1) promotes differentiation by reducing Notch signaling through a Cis-inhibition mechanism. However, during the delamination process, the ubiquitin ligase Mindbomb1 (Mib1) transiently blocks this Cis-inhibition and sustains Notch activity to defer differentiation. We propose that the fine-tuned balance between Notch Trans-activation and Cis-inhibition allows neuroepithelial cells to seamlessly delaminate from the ventricular wall as they commit to differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.