Evidence map›Paper›PMID 29708404›Full record

ArticleCNS oncology2018

BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma.

Rimas V Lukas, Ryan T Merrell

Open access · goldAbstract readCase Reports
In one paragraph

Article in CNS oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The evolution of pleomorphic xanthoastrocytoma: from genesis to molecular alterations and mimics.Laboratory investigation; a journal of technical methods and pathology · 2022
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rimas V LukasDepartment of Neurology, Lurie Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Ryan T MerrellDepartment of Neurology, Northshore University HealthSystem, Evanston, IL 60201, USA.
GTx (United States) · USNorthShore University HealthSystem · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case.

Indexed as

Electric Stimulation TherapyAntineoplastic AgentsAstrocytomaBrain NeoplasmsCombined Modality TherapyFatal OutcomeFemaleHumansProtein Kinase InhibitorsProto-Oncogene Proteins B-rafVemurafenibYoung AdultAntineoplastic AgentsBRAF protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins B-rafVemurafenibBRAFOptunepleomorphic xanthoastrocytomatumor treating fieldsvemurafenib

Identifiers

PMID29708404
PMCPMC5977279
OpenAlexW2799741393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.