ArticleThe Angle orthodontist2018
Effects of growth hormone and functional appliance on mandibular growth in an adolescent rat model.
Article in The Angle orthodontist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Anterior Mandibular Displacement in Growing Rats Enhances Growth-A 3D Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Craniofacial anatomical determinants of pediatric sleep-disordered breathing: A comprehensive review.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025Review
- Establishment of a mandible defect model in rabbits infected with multiple bacteria and bioinformatics analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Comparison of part-time and full-time mandibular advancement: enlightenment based on type H vessel coupling osteogenesis.Clinical oral investigations · 2023Article
- The Condylar Effects of Mesenchymal Stem Cells, Low-Level Laser Therapy and Grape Seed Extract on Functional Mandibular Advancement of the Rat Mandible.Turkish journal of orthodontics · 2023Article
- Mandibular condylar process remodeling in rats with different bite-altering devices.European cells & materials · 2023Article
- Anterior Mandibular Displacement in Growing Rats-A Systematic Review.Animals : an open access journal from MDPI · 2022Review
- [Morphological change analysis based on cone beam CT of the upper airway for obstructive sleep apnea syndrome patients treated with oral appliance in skeletal class Ⅱ malocclusion with different vertical patterns].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Article
- Article
- Role of salivary Insulin-like Growth Factor-1 (IGF-1) in the regulation of biomechanical process following mandibular advancement with a twin block appliance-a prospective observational study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the individual and synergistic effects of growth hormone (GH) and functional appliance (FA) on mandibular growth in an adolescent rat model. MATERIALS AND
methodsForty adolescent (6-week-old) female Wistar rats were randomly divided into four groups (10 rats in each group). The control group received a sham treatment (intra-abdominal injection of phosphate-buffered saline), the GH group received an intra-abdominal injection of recombinant human growth hormone, the FA group was treated with a mandibular advancement device, and the GH+FA group received both the GH and FA treatments. The amount of mandibular growth in each group was measured quantitatively using cone-bean computed tomography. The growth of condylar cartilage and expression of matrix metalloproteinases-1 and -13 (MMP-1 and MMP-13) and type II and X collagen (Col II and Col X) were assessed using histological staining and immunostaining techniques.
resultsAfter 4 weeks, there was significant mandibular growth in the FA group compared with the control group ( P < .05). The GH+FA group had significantly greater mandibular length, thickness of condylar cartilage, and expression of MMP-1, MMP-13, Col II, and Col X in the cartilage than the other groups ( P < .05). The GH+FA group and GH group had significantly greater weight than the FA and control groups ( P < .05).
conclusionsThe FA as well as GH+FA stimulated mandibular growth in adolescent rats.
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