ArticleThe Journal of physiology2018
Functional decoupling of melatonin suppression and circadian phase resetting in humans.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Managing Sleep in Bipolar Disorder: An Overview of Pharmacological and Non-Pharmacological Interventions.Bipolar disorders · 2026Pooled it
- Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.Journal of biological rhythms · 2023Trial
- Characterizing the temporal Dynamics of Melatonin and Cortisol Changes in Response to Nocturnal Light Exposure.Scientific reports · 2019Trial
- Circadian timing does not modulate human temporal contrast sensitivity.Journal of vision · 2026Article
- Light pollution: environmental and health impacts at high latitudes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- Salivary hormones in depression: the future in diagnosis and treatment.Annals of general psychiatry · 2025Review
- Estimating dim light melatonin onset time in children using delta changes in melatonin.Sleep and biological rhythms · 2024Article
- Greater sensitivity of the circadian system of women to bright light, but not dim-to-moderate light.Journal of pineal research · 2024Article
- Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults.Journal of physiological anthropology · 2023Review
- Dynamic lighting schedules to facilitate circadian adaptation to shifted timing of sleep and wake.Journal of pineal research · 2022Article
- Influence of Wearing Blue Lenses on Melatonin Production and Performance in Volleyball Players.Sports medicine international open · 2022Article
- Melanopsin-driven pupil response in summer and winter in unipolar seasonal affective disorder.Journal of affective disorders · 2021Article
- Reply to Bracke et al. Comment on "Prayag et al. Light Modulation of Human Clocks, Wake, and Sleep.Clocks & sleep · 2021Article
- Blunted rest-activity rhythms link to higher body mass index and inflammatory markers in children.Sleep · 2021Observational
- Human-Centric Lighting: Foundational Considerations and a Five-Step Design Process.Frontiers in neurology · 2021Review
- Correlated color temperature and light intensity: Complementary features in non-visual light field.PloS one · 2021Article
- Predictions of melatonin suppression during the early biological night and their implications for residential light exposures prior to sleeping.Scientific reports · 2020Article
- Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.Current biology : CB · 2019Article
- Melanopsin contributions to non-visual and visual function.Current opinion in behavioral sciences · 2019Article
- Effects of light on human circadian rhythms, sleep and mood.Somnologie : Schlafforschung und Schlafmedizin = Somnology : sleep research and sleep medicine · 2019Article
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8 authors.
Funding
Abstract
key pointsThere is assumed to be a monotonic association between melatonin suppression and circadian phase resetting induced by light exposure. We tested the association between melatonin suppression and phase resetting in humans. Sixteen young healthy participants received nocturnal bright light (∼9500 lux) exposure of continuous or intermittent patterns, and different durations ranging from 12 min to 6.5 h. Intermittent exposure patterns showed significant phase shifts with disproportionately less melatonin suppression. Each and every bright light stimulus in an intermittent exposure pattern induced a similar degree of melatonin suppression, but did not appear to cause an equal magnitude of phase shift. These results suggest that phase shifts and melatonin suppression are functionally independent such that one cannot be used as a proxy measure of the other. ABSTRACT: Continuous experimental light exposures show that, in general, the conditions that produce greater melatonin suppression also produce greater phase shift, leading to the assumption that one can be used as a proxy for the other. We tested this association in 16 healthy individuals who participated in a 9-day inpatient protocol by assessing melatonin suppression and phase resetting in response to a nocturnal light exposure (LE) of different patterns: (i) dim-light control (<3 lux; n = 6) or (ii) two 12-min intermittent bright light pulses (IBL) separated by 36 min of darkness (∼9500 lux; n = 10). We compared these results with historical data from additional LE patterns: (i) dim-light control (<3 lux; n = 11); (ii) single continuous bright light exposure of 12 min (n = 9), 1.0 h (n = 10) or 6.5 h (n = 6); or (iii) an IBL light pattern consisting of six 15-min pulses with 1.0 h dim-light recovery intervals between them during a total of 6.5 h (n = 7). All light exposure groups had significantly greater phase-delay shifts than the dim-light control condition (P < 0.0001). While a monotonic association between melatonin suppression and circadian phase shift was observed, intermittent exposure patterns showed significant phase shifts with disproportionately less melatonin suppression. Each and every IBL stimulus induced a similar degree of melatonin suppression, but did not appear to cause an equal magnitude of phase shift. These results suggest unique specificities in how light-induced phase shifts and melatonin suppression are mediated such that one cannot be used as a proxy measure of the other.
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