Evidence map›Paper›PMID 29707696›Full record

ArticleImmunoHorizons2018

Clonal Bifurcation of Foxp3 Expression Visualized in Thymocytes and T Cells.

Bonnie Yen, Katherine T Fortson, Nyanza J Rothman, Nicholas Arpaia, Steven L Reiner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ImmunoHorizons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bonnie YenDepartment of Microbiology and Immunology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Katherine T FortsonDepartment of Microbiology and Immunology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Nyanza J RothmanDepartment of Microbiology and Immunology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Nicholas ArpaiaDepartment of Microbiology and Immunology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Steven L ReinerDepartment of Microbiology and Immunology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Columbia University · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Asymmetric Lymphocyte Division in the Immune ResponseR01AI076458 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI REINER, STEVEN L · 2008 to 2019
$3.7M
Diversifying and Regenerating T Cell FunctionR01AI113365 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REINER, STEVEN L · 2014 to 2018
$2.0M
Self-renewing Lymphocyte Division in The Immune ResponseR56AI076458 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REINER, STEVEN L · 2014 to 2021
$802k
Mechanisms mediating tissue repair by leukocytes during influenza virus infectionK22AI127847 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPAIA, NICHOLAS · 2017 to 2018
$266k
NCI NIH HHS P30 CA013696NIAID NIH HHS K22 AI127847NIAID NIH HHS R01 AI076458NIAID NIH HHS R01 AI113365NIAID NIH HHS R56 AI076458NIGMS NIH HHS T32 GM007367
6 · The paper itself

Abstract

Regulatory T cells (Tregs) are crucial for suppressing autoimmunity and inflammation mediated by conventional T cells. To be useful, some Tregs should have overlapping specificity with relevant self-reactive or pathogen-specific clones. Whether matching recognition between Tregs and non-Tregs might arise through stochastic or deterministic mechanisms has not been addressed. We tested the hypothesis that some Tregs that arise in the thymus or that are induced during Ag-driven expansion of conventional CD4

Identifiers

PMID29707696
PMCPMC5922779
OpenAlexW2796841390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.