ArticleJournal of preventive medicine and hygiene2017
Molecular analysis of immune evasion cluster (IEC) genes and intercellular adhesion gene cluster (ICA) among methicillin-resistant and methicillin-sensitive isolates of
Article in Journal of preventive medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance.Journal of applied microbiology · 2022Pooled it
- Genetic diversity, virulence factors and antimicrobial resistance profiles of S. aureus isolated from raw meat, meat products and veterinary samples of food-producing animals in South African provinces.BMC microbiology · 2026Article
- Comparative genomics of endemicmSphere · 2025Article
- Decoding the evolutionary history of ST30Frontiers in microbiology · 2025Article
- Prevalence of Selected Immune Evasion Genes and Clonal Diversity in Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2024Article
- Whole genome sequencing of methicillin-resistant Staphylococcus aureus clinical isolates from Terengganu, Malaysia, indicates the predominance of the EMRSA-15 (ST22-SCCmec IV) clone.Scientific reports · 2024Article
- Molecular Characterization ofMicroorganisms · 2023Article
- Synergistic Inhibitory Effect of Honey andPathogens (Basel, Switzerland) · 2023Article
- Genomic epidemiology and characterization ofFrontiers in microbiology · 2023Article
- A review of new emerging livestock-associated methicillin-resistantVeterinary world · 2023Review
- Anthroponotic-Based Transfer ofPathogens (Basel, Switzerland) · 2022Article
- Antibacterial Activity of Chinese Red Propolis againstMolecules (Basel, Switzerland) · 2022Article
- Detection, molecular characterization, and antibiogram of multi-drug resistant and methicillin-resistantIranian journal of veterinary research · 2021Article
- Genome-Wide Profiling of EnterotoxigenicGenes · 2019Article
- Virulence of methicillin-resistant Staphylococcus aureus modulated by the YycFG two-component pathway in a rat model of osteomyelitis.Journal of orthopaedic surgery and research · 2019Article
- Genetic characterization of two vancomycin-resistantInfection and drug resistance · 2019Article
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4 authors.
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Abstract
introductionResistance to antibiotics and presence of virulence factors play an important role in increased mortality associated with infection due to Staphylococcus aureus. In this study, we determine antibiotic resistance pattern, presence of the icaADBC locus as well as biofilm formation and distribution and diversity the immune evasion cluster (IEC) genes in clinical isolate of S. aureus from Kerman, Iran. MATERIALS AND
methodsDuring 15 months, 100 clinical isolates S. aureus recovered from different patients were admitted to Kerman University affiliated hospitals. Resistance to different antibiotic agents was determined by disk diffusion method. Phenotypic method was used to the determination of biofilm formation ability and methicillin-resistance S. aureus (MRSA). Polymerase chain reaction technique (PCR) was used to the detection of nuc, mecA, icaA, icaD, icaB, icaC, scn, sea, sak, sep and chp genes.
resultsForty-four isolates were considered as MRSA and all of isolates were sensitive to vancomycin and linezolid. Our results showed, 77.2% (34/44) of MRSA and 8.9 % (5/56) of MSSA isolates were multidrug resistant. The predominant IEC variant was type B and our results displayed that 77.7% of the MRSA isolates harbor loci icaD and mecA. There was no significant difference in production biofilm between MSSA and MRSA isolates (P ≥ 0.05). There was significant difference in presence IEC types between MSSA and MRSA isolates (P = 0.000).
conclusionsThe presence of icaADBC locus may not be a determining factor for biofilm formation in Staphtlocooci and other mechanisms might be involved in this process.The high prevalence IEC types in MSSA isolates can indicate that the presence of these genes can be an advantage for pathogenesis of these isolates in different infections.
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